|别 名||AKIRIN 1; C1orf108; FLJ12666; OTTHUMP00000008669; RP11-781D11.2; STRF2; AKIR1_HUMAN.|
|规格价格||100ul/1580元 购买 200ul/2480元 购买 大包装/询价|
|说 明 书||100ul 200ul|
|研究领域||细胞生物 免疫学 表观遗传学|
|交叉反应||Human, Mouse, Rat, Dog, Horse, Sheep,|
|产品应用||ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||22kDa|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated synthetic peptide derived from human AKIRIN1:101-192/192|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
AKIRIN1 is dispensable in the mouse, and neither knockout mice nor cells derived from them have obvious distinctive phenotypes. In contrast, Akirin2 is required for development in the mouse and knockout of both Akirin homologs in mice show that Akirin2 is required downstream of toll-like receptor (TLR), TNF-alpha and IL-1beta signaling, and for the production of IL-6. Akirin2 is functionally closer to the single gene in Drosophila, as the homozygous null D. melanogaster Akirin mutants show a similar, mid-to-early embryonic death.The highly conserved, nuclear-localized AKIRIN1 and Akirin2 proteins critically regulate the transcription of NF-kB dependent genes and are required for defense against Gram-negative bacteria in the immune deficiency and NF-kB pathways.
Widely expressed with the highest expression in heart, liver, placenta and peripheral blood leukocytes.
Belongs to the akirin family.
Entrez Gene: 79647 Human
Entrez Gene: 68050 Mouse
Entrez Gene: 595134 Rat
Omim: 615164 Human
SwissProt: Q9H9L7 Human
SwissProt: Q99LF1 Mouse
Unigene: 293563 Human
Unigene: 27903 Mouse
Unigene: 390996 Mouse
Unigene: 486258 Mouse
Unigene: 3674 Rat
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.