肾病样蛋白1抗体北京博奥森生物技术有限公司

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性能参数

产品名称: 肾病样蛋白1抗体
英文名称: Anti-KIRREL1
抗体货号: bs-6435R
产品规格: 100ul
产品产地: 中国
品牌商标: Bioss
价    格: 1580元
抗原: KIRREL1
抗原来源: KLH conjugated synthetic peptide derived from huma
抗体来源: Rabbit
适用物种: Human,Mouse,Rat,
无conjugate:无
Isotype:IgG
应用范围: WB:1:500-2000 IHC-P:1:400-800 IHC-F:1:400-800 IF:1:100-500 ELISA:1:500-1000
更新时间: 2019/5/1 13:22:00
详细资料:  实验方法技术资料
浏览人数:7
诚信指数:1428点
了解更多:进入公司展台
使用范围:仅限科研使用,不能应用于临床
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生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

供应商联系卡

北京博奥森生物技术有限公司
地址:
北京市通州区马驹桥镇联东U谷西区四期67号楼
邮编:
101102
电话:
4009019800
传真:
010-58129612
联系人:
所在区域:
北京·北京
邮件:
公司展台:

产品详细描述

WB:1:500-2000 IHC-P:1:400-800 IHC-F:1:400-800  IF:1:100-500  ELISA:1:500-1000; Neph1(Kirrel) belongs to a family of three closely related transmembrane proteins of the Ig superfamily with a structure similar to that of nephrin. Neph1 consists of a signal peptide, five Ig-like C2-type domains with the middle domain overlapping with a PKD-like domain, an RGD sequence, a transmembrane domain and a cytoplasmic tail. Neph1 is abundantly expressed in the kidney, specifically expressed in podocytes of kidney glomeruli, and plays a significant role in the normal development and function of the glomerular permeability. Neph1 interacts with nephrin in vitro and in vivo, and able to stimulate transcriptional activation in a model system, such as the activation the transcription factor AP-1 via the stimulation of a MAPK module. Neph1 is crucial for the integrity of the slit diaphragm, as Neph1 gene knockout mice results in effacement of glomerular podocytes, heavy proteinuria, and early postnatal death.  .
Tissue specificity:
Abundantly expressed in kidney. Specifically expressed in podocytes of kidney glomeruli.

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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