Anti-Synaptojanin 2/FITC Conjugated抗体
产品名称： Anti-Synaptojanin 2/FITC Conjugated抗体
英文名称： Anti-Synaptojanin 2/FITC
产品编号： YB--11377R-FITC
产品价格： null
产品产地： 中国/美国
品牌商标： Ybscience
更新时间： 2023-08-17T10:29:50
使用范围： 科研使用
上海钰博生物科技有限公司
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- 邮编 : 200612
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Anti-Synaptojanin 2/FITC Conjugated抗体
| 产品编号 | YB-11377R-FITC |
| 英文名称 | Anti-Synaptojanin 2/FITC |
| 中文名称 | FITC标记的磷酸肌醇磷酸酶蛋白INPP5H抗体 |
| 别 名 | INPP5H; 5-trisphosphate 5-phosphatase 2; Inositol phosphate 5' phosphatase 2; INPP 5H; INPP5H; KIAA0348; MGC44422; SJ2; Synaptic inositol 1 4 5 trisphosphate 5 phosphatase 2; Synaptic inositol-1; Synaptojanin-2; Synaptojanin2; SYNJ 2; Synj2; SYNJ2_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 信号转导 G蛋白信号 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 165kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Synaptojanin 2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The inositol polyphosphate 5-phosphatases selectively remove the phosphate from the 5-position of various phosphatidylinositols, which generate second messengers in response to extracellular signals. Synaptojanins are characterized by an N-terminal SAC1-like sequence, a central 5-phosphate domain, and a unique C-terminal sequence and have been shown to use phosphatidylinositol 4,5-bisphosphate as a substrate. Synaptojanins exist as two isoforms, synaptojanin 1 and 2, which differ in the C-terminal domain, and each isoform has multiple variants produced by alternative splicing. Synaptojanin 1 is expressed as two major forms: the shorter is found in brain while the longer is expressed in peripheral tissues. Eight splice variants of synaptojanin 2 have been detected, including a brain specific isoform. Synaptojanins are thought to participate in the endocytosis of synaptic vesicles and the regulation of the actin cytoskeleton. Function: Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis. Subunit: Binds to GRB2. Isoform 2A binds to SYNJ2BP/OMP25. Isoform 2B2 C-terminal proline-rich region binds to a variety of SH3 domain-containing proteins including SH3GL1, SH3GL2, SH3GL3 and GRB2. Subcellular Location: Membrane. Note=Predominantly associated with the particulate fractions. Similarity: Belongs to the synaptojanin family. In the central section; belongs to the inositol-1,4,5-trisphosphate 5-phosphatase family. Contains 1 RRM (RNA recognition motif) domain. Contains 1 SAC domain. Database links: Entrez Gene: 8871 Human Omim: 609410 Human SwissProt: O15056 Human Unigene: 434494 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |