Anti-GTP binding protein REM1/FITC Conjugated抗体-抗体-抗体-生物在线

Anti-GTP binding protein REM1/FITC Conjugated抗体

商家询价

产品名称： Anti-GTP binding protein REM1/FITC Conjugated抗体

英文名称： Anti-GTP binding protein REM1/FITC

产品编号： YB--7502R-FITC

产品价格： null

产品产地：中国/美国

品牌商标： Ybscience

更新时间： 2023-08-17T10:29:50

使用范围：科研使用

上海钰博生物科技有限公司

联系人 : 陈环环
地址 : 上海市沪闵路6088号龙之梦大厦8楼806室
邮编 : 200612
所在区域 : 上海
电话 : 183****2235
传真 : 021-60514606
邮箱 : shybio@126.com

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产品详情

Anti-GTP binding protein REM1/FITC Conjugated抗体

产品编号	YB-7502R-FITC
英文名称	Anti-GTP binding protein REM1/FITC
中文名称	FITC标记的GTP结合蛋白REM1抗体
别名	Rad and Gem related GTP binding protein; GES; GTP binding protein REM; GTP binding protein REM 1; GTP binding protein REM1; GTPase GES; GTPase regulating endothelial cell sprouting; Rad and Gem like GTP binding protein 1; RAS (RAD and GEM) like GTP binding; RAS like GTP binding; RAS like GTP binding protein REM; REM 1; REM1; E030011C07Rik; RP23-35I8.9; GD:REM; MGC114556; MGC48669; OTTMUSP00000016855; REM1_HUMAN.
规格价格	100ul/2980元购买大包装/询价
说明书	100ul
研究领域	心血管细胞生物信号转导生长因子和激素转录调节因子通道蛋白血管内皮细胞 G蛋白信号
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep,
产品应用	IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	33kDa
性状	Lyophilized or Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human REM/GTP binding protein REM1
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.
产品介绍	background: REM (Rad and Gem related GTP binding protein) is a member of the Rad/Gem/Kir subfamily of Ras-like GTPases and shares with other members of this subfamily some unusual structural features. Among these are nonconservative amino acid substitutions within guanine nucleotide binding and hydrolysis domains, unique effector domains, extended N- and C-termini, and a conserved C-terminal sequence thought to mediate membrane association but lacking a classical isoprenylation motif. REM, with a predicted molecular weight of 32.9 kDa, is most highly expressed in cardiac muscle and is expressed at more moderate levels in lung, kidney and skeletal muscle. REM is phosphorylated in vivo and has been shown to interact with several 14-3-3 isoforms. It has been reported that the GTP-bound form of a related Ras-like GTPase, GEM/kir, inhibits high-voltage activated Ca2+ channel activities by interacting directly with the ?subunit. The reduced channel activities are the result of a decreased a-subunit expression at the plasma membrane. This inhibition of L-type Ca2+ channels prevents Ca2+-triggered exocytosis in hormone-secreting cells. There are data that suggest that REM similarly regulates Ca2+ channel expression. Function: Promotes endothelial cell sprouting and actin cytoskeletal reorganization. May be involved in angiogenesis. May function in Ca(2+) signaling. Subunit: In vitro, interacts with calmodulin in a calcium-dependent manner. Tissue Specificity: Most highly expressed in the endothelial lining of the blood vessels in uterus and heart. Lower levels found in spleen, lymph node, kidney and testis. Also found in cells with secretory function such as the islets of Langerhans, lobule/duct epithelium in the breast, bile duct epithelium in the liver, surface epithelium in the endometrial glands of the uterus, colon mucosa and acinar cells in the pancreas and the prostate. Similarity: Belongs to the small GTPase superfamily. RGK family. Database links: UniProtKB/Swiss-Prot: O75628.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.