Anti-KCNK3/FITC Conjugated抗体上海钰博生物科技有限公司

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产品名称: Anti-KCNK3/FITC Conjugated抗体
英文名称: Anti-KCNK3/FITC
抗体货号: YB--2963R-FITC
产品规格: 20ul/50ul/100ul/200ul
级    别: , 分析纯, 见说明书
产品产地: 中国/美国
品牌商标: Ybscience
价    格: 2980元
抗原: KLH conjugated synthetic peptide derived from human KCNK3
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: Human, Mouse, Rat, Dog, Cow,
见说明书conjugate:见说明书
Isotype:见说明书
应用范围: 科研使用
更新时间: 2019/4/16 11:06:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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产品详细描述

 Anti-KCNK3/FITC Conjugated抗体

产品编号 YB-2963R-FITC
英文名称 Anti-KCNK3/FITC
中文名称 FITC标记的酸敏感性钾离子通道蛋白抗体
别    名 cTBAK 1; Acid sensitive potassium channel protein TASK 1; Cardiac two pore background K(+) channel; K2p3.1; OAT1; potassium channel, subfamily K, member 3; rTASK; TASK 1; TBAK1; TWIK related acid sensitive K+ channel; Two pore potassium channel KT3.1; KCNK3; TASK; TASK1; PPH4; TASK; TASK-1; TBAK1; KCNK3_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 神经生物学  通道蛋白  细胞膜受体  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 43kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human KCNK3
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
KCNK9 or TASK-3 (TWIK-related Acid sensitive K+ channel) is a member of the potassium channel family of proteins that contain two-pore domain and four transmembrane domains. These channels are characterized as leak K+ channels that are sensitive to changes in the extracellular pH. The physiological functions of TASK channels are largely unknown; it has been proposed that they may be involved in the regulation of breathing, aldosterone secretion and anesthetic-mediated neuronal activity. They were found to act in neurons' membrane potential and in resting K+ currents. KCNK9 gene has been localized to the chromosomal region 8q24. The protein is expressed at high levels mainly in the brain and at low levels in other tissues. In contrast to normal tissues, it was found that KCNK9 is amplified in some human carcinomas such as breast, lung, colon and metastatic prostate. In 10% of breast cancer patients this gene is amplified, and in 44% the protein is over expressed. Monoclonal antibodies to KNCK9 are an important tool for studying the potassium channel family of proteins in different tissues.

Function:
pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward. 

Subcellular Location:
Membrane; Multi-pass membrane protein (Potential).

Tissue Specificity:
Widespread expression in adult. Strongest expression in pancreas and placenta. Lower expression in brain, lung, prostate, heart, kidney, uterus, small intestine and colon. 

Similarity:
Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. 

Database links:

Entrez Gene: 3777 Human

Entrez Gene: 16527 Mouse

Entrez Gene: 29553 Rat

Omim: 603220 Human

SwissProt: O14649 Human

SwissProt: Q53SU2 Human

SwissProt: O35111 Mouse

SwissProt: O54912 Rat

Unigene: 645288 Human

Unigene: 439936 Mouse

Unigene: 15536 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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