Anti-Desmocollin 2 + 3/FITC Conjugated抗体上海钰博生物科技有限公司

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产品名称: Anti-Desmocollin 2 + 3/FITC Conjugated抗体
英文名称: Anti-Desmocollin 2 + 3/FITC
抗体货号: YB--2983R-FITC
产品规格: 20ul/50ul/100ul/200ul
级    别: , 分析纯, 见说明书
产品产地: 中国/美国
品牌商标: Ybscience
价    格: 2980元
抗原: KLH conjugated synthetic peptide derived from human Desmocollin 2
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: Human, Mouse, Rat, Horse,
见说明书conjugate:见说明书
Isotype:见说明书
应用范围: 科研使用
更新时间: 2019/4/16 11:07:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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产品详细描述

 Anti-Desmocollin 2 + 3/FITC Conjugated抗体

产品编号 YB-2983R-FITC
英文名称 Anti-Desmocollin 2 + 3/FITC
中文名称 FITC标记的桥粒糖蛋白2/桥粒糖蛋白3抗体
别    名 ARVD11; Cadherin family member 2; CDHF2; Desmocollin 3; Desmocollin3; Desmocollin-2; Desmocollin-3; Desmocollin2; Desmosomal glycoprotein II and III; Desmosomal glycoprotein II; Desmosomal glycoprotein II/III; Desmosomal glycoprotein III; DG2; DGII/III; DKFZp686I11137; DSC 2; DSC2; DSC2_HUMAN; DSC3.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 心血管  细胞生物  信号转导  细胞粘附分子  细胞表面分子  细胞骨架  细胞外基质  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Horse, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 84kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Desmocollin 2
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11. Alternative splicing results in two transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Function:
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.

Subunit:
Interacts with DSP, PKP2 and JUP.

Subcellular Location:
Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome.

Tissue Specificity:
In all epithelia tested and heart.

DISEASE:
Defects in DSC2 are the cause of familial arrhythmogenic right ventricular dysplasia type 11 (ARVD11) [MIM:610476]; also known as arrhythmogenic right ventricular cardiomyopathy 11 (ARVC11). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall.

Similarity:
Contains 5 cadherin domains.

Database links:

Entrez Gene: 1824 Human

Entrez Gene: 1825 Human

Omim: 125645 Human

Omim: 600271 Human

SwissProt: Q02487 Human

SwissProt: Q14574 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

Involvement in disease:Defects in DSC2 are the cause of familial arrhythmogenic right ventricular dysplasia type 11 (ARVD11); also known as arrhythmogenic right ventricular cardiomyopathy 11 (ARVC11). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wal

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