产品名称： Anti-Ubiquitously expressed transcript//FITC Conjugated抗体
英文名称： Anti-Ubiquitously expressed transcript/FITC
级 别： , 分析纯, 见说明书
价 格： 2980元
抗原： KLH conjugated synthetic peptide derived from human UXT/Ubiquitously expressed transcript
适用物种： Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
更新时间： 2019/4/16 11:08:00
Anti-Ubiquitously expressed transcript//FITC Conjugated抗体
|英文名称||Anti-Ubiquitously expressed transcript/FITC|
|别 名||Androgen receptor trapped clone 27 protein; ART 27; Protein UXT; Ubiquitously expressed transcript; Ubiquitously expressed transcript protein; UXT_HUMAN.|
|规格价格||100ul/2980元 购买 大包装/询价|
|说 明 书||100ul|
|研究领域||肿瘤 细胞生物 信号转导 转录调节因子 肿瘤细胞生物标志物 表观遗传学|
|交叉反应||Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,|
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||18kDa|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated synthetic peptide derived from human UXT/Ubiquitously expressed transcript|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
UXT is a novel protein, highly conserved in mouse. It interacts with the N terminus of the androgen receptor and plays a role in facilitating receptor-induced transcriptional activation. It is abundantly expressed in tumor tissues and is likely to be involved in tumorigenesis.
Involved in gene transcription regulation. Acts in concert with the corepressor URI1 to regulate androgen receptor transcription (AR). AR N-terminus-associated coactivator which may play a role in facilitating receptor-induced transcriptional activation (PubMed:11854421). Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling (PubMed:11827465). Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC (PubMed:17554592). May be a nuclear chaperone that promotes formation of the NF-kappa-B enhanceosome and which is essential for its nuclear function (PubMed:17620405). Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM (PubMed:17635584). Together with URI1, associates with chromatin to the NKX3-1 promoter region.
Homohexamer. Interacts with LRPPRC. Interacts with AR N-terminus. In the nucleus interacts specifically with RELA and forms a dynamic complex with NF-kappa-B and is recruited to the NF-kappa-B enhanceosome upon stimulation. Interacts with MECOM and URI1.
Ubiquitous. Expressed in prostate epithelial cells. Overexpressed in a number of tumor tissues (PubMed:16221885). Highest levels in the heart, skeletal muscle, pancreas, kidney, liver, adrenal gland, peripheral blood leukocytes, lymph node, prostate, and thyroid and the lowest levels in bladder and uterus.
Belongs to the UXT family.
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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