Anti-APG4B/FITC Conjugated抗体
产品名称： Anti-APG4B/FITC Conjugated抗体
英文名称： Anti-APG4B/FITC
产品编号： YB--1384R-FITC
产品价格： null
产品产地： 中国/美国
品牌商标： Ybscience
更新时间： 2023-08-17T10:29:50
使用范围： 科研使用
上海钰博生物科技有限公司
- 联系人 : 陈环环
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- 邮编 : 200612
- 所在区域 : 上海
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- 传真 : 021-60514606
- 邮箱 : shybio@126.com
Anti-APG4B/FITC Conjugated抗体
| 产品编号 | YB-1384R-FITC |
| 英文名称 | Anti-APG4B/FITC |
| 中文名称 | FITC标记的自噬相关蛋白4B抗体 |
| 别 名 | APG4B; ATG4 autophagy related 4 homolog B (S. cerevisiae); AUT like 1 cysteine endopeptidase; AUTL1; Autophagin 1; Autophagy related cysteine endopeptidase 1; Autophagy related protein 4 homolog B; Cysteine protease ATG4B; hAPG4B; MGC1353br. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞凋亡 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 44kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human APG4B |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] Function: Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes. Subcellular Location: Cytoplasm (Probable). Tissue Specificity: Mainly expressed in the skeletal muscle, followed by brain, heart, liver and pancreas. Similarity: Belongs to the peptidase C54 family. Database links: Entrez Gene: 23192 Human Entrez Gene: 66615 Mouse Entrez Gene: 316640 Rat Omim: 611338 Human SwissProt: Q9Y4P1 Human SwissProt: Q8BGE6 Mouse SwissProt: Q62625 Rat Unigene: 283610 Human Unigene: 29087 Mouse Unigene: 163086 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 细胞自噬（Autophagy）是一种非凋亡性的程序性细胞死亡即自噬性程序性细胞死亡，进化过程中高度保守，清除降解细胞内受损伤的细胞结构、衰老的细胞器、以及不再需要的生物大分子等，在细胞的生长、发育和疾病发生中起着重要的作用。细胞自噬是一个高效调控过程，特异性激酶和鸟嘌呤核苷酸磷酸酶（GTPases）在调节自噬通道活性中起着关键作用. |