Anti-ROCK2/FITC Conjugated抗体上海钰博生物科技有限公司

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产品名称: Anti-ROCK2/FITC Conjugated抗体
英文名称: Anti-ROCK2/FITC
抗体货号: YB--1205R-FITC
产品规格: 20ul/50ul/100ul/200ul
级    别: , 分析纯, 见说明书
产品产地: 中国/美国
品牌商标: Ybscience
价    格: 2980元
抗原: KLH conjugated synthetic peptide derived from human ROCK2
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: Human, Mouse, Rat, Rabbit,
见说明书conjugate:见说明书
Isotype:见说明书
应用范围: 科研使用
更新时间: 2019/5/16 10:21:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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产品详细描述

 Anti-ROCK2/FITC Conjugated抗体

产品编号 YB-1205R-FITC
英文名称 Anti-ROCK2/FITC
中文名称 FITC标记的Rho相关蛋白激酶2抗体
别    名 p164 ROCK 2; p164 ROCK-2; Rho associated coiled coil containing protein kinase 2; Rho associated protein kinase 2; Rho kinase 2; ROCK 2; Rock II; Rock2m; ROK alpha; ROKalpha; coiled-coil-containing protein kinase 2; KIAA0619; Rho associated, coiled coil containing protein kinase II; Rho-associated; Rho-associated protein kinase 2; Rock2; ROCK2_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  细胞生物  信号转导  细胞凋亡  激酶和***酸酶  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Rabbit, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 161kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ROCK2
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho. [provided by RefSeq, Jul 2008].

Function:
Regulates the assembly of the actin cytoskeleton. Promotes formation of stress fibers and of focal adhesion complexes. Plays a role in smooth muscle contraction.

Subcellular Location:
Cytoplasm. Cell membrane. Cytoplasmic, and associated with actin microfilaments and the plasma membrane.

Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.Phosphorylation at Tyr-722 reduces its binding to RHOA and iscrucial for focal adhesion dynamics. Dephosphorylation by PTPN11stimulates its RHOA binding activity. 
Cleaved by granzyme B during apoptosis. This leads toconstitutive activation of the kinase and membrane blebbing.

Similarity:
Belongs to the protein kinase superfamily. AGC Ser/Thrprotein kinase family. 
Contains 1 AGC-kinase C-terminal domain. 
Contains 1 PH domain. 
Contains 1 phorbol-ester/DAG-type zinc finger. 
Contains 1 protein kinase domain. 
Contains 1 REM (Hr1) repeat.

Database links:

Entrez Gene: 9475 Human

Entrez Gene: 19878 Mouse

Entrez Gene: 25537 Rat

Omim: 604002 Human

SwissProt: O75116 Human

SwissProt: P70336 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

ROCK2(Rho kinase alpha)是ROCK1的同工酶。是一个丝/苏氨基酸激酶,可调节细胞因子,平滑肌收缩和肌动蛋白的形成

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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