Anti-P311 protein/FITC Conjugated抗体上海钰博生物科技有限公司

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产品名称: Anti-P311 protein/FITC Conjugated抗体
英文名称: Anti-P311 protein/FITC
抗体货号: YB--0427R-FITC
产品规格: 20ul/50ul/100ul/200ul
级    别: , 分析纯, 见说明书
产品产地: 中国/美国
品牌商标: Ybscience
价    格: 2980元
抗原: KLH conjugated synthetic peptide derived from human P311 N-terminus
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: Human, Mouse, Rat,
见说明书conjugate:见说明书
Isotype:见说明书
应用范围: 科研使用
更新时间: 2019/6/5 12:04:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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产品详细描述

 Anti-P311 protein/FITC Conjugated抗体

产品编号 YB-0427R-FITC
英文名称 Anti-P311 protein/FITC
中文名称 FITC标记的神经再生相关蛋白抗体
别    名 C5orf13; Neuronal protein 3.1; PRO1873; Protein p311; Chromosome 5 open reading frame 13; D4S114; PTZ17; NREP_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  心血管  细胞生物  神经生物学  细胞周期蛋白  细胞分化  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 7.9kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human P311 N-terminus
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
P311, also called PTZ17, was identified by suppressive subtraction hybridization as potentially involved in smooth muscle (SM) myogenesis., an 8-kDa polypeptide, was previously shown to be highly expressed in invasive glioma cells. P311 is constitutively serine-phosphorylated; decreased phosphorylation is observed in migration-activated glioma cells. The primary amino acid sequence of P311 indicates a putative serine phosphorylation site (S59) near the PEST domain. Site-directed mutagenesis of S59A retarded P311 degradation and induced glioma cell motility. In contrast, S59D mutation resulted in the rapid degradation of P311 and reduced glioma cell migration. 

Function:
May have roles in neural function. Ectopic expression augments motility of gliomas. Promotes also axonal regeneration (By similarity). May also have functions in cellular differentiation (By similarity). Induces differentiation of fibroblast into myofibroblast and myofibroblast ameboid migration. Increases retinoic-acid regulation of lipid-droplet biogenesis (By similarity). Down-regulates the expression of TGFB1 and TGFB2 but not of TGFB3 (By similarity). May play a role in the regulation of alveolar generation.

Subunit:
Interacts with the latency-associated peptides (LAP) of TGFB1 and TGFB2; the interaction results in a decrease in TGFB autoinduction (By similarity). Interacts with FLNA.

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Expressed in lung (at protein level).

Post-translational modifications:
Phosphorylated on Ser-59. Phosphorylation decreases stability and activity.

Database links:

Entrez Gene: 9315 Human

Entrez Gene: 27528 Mouse

Entrez Gene: 338475 Rat

Omim: 607332 Human

SwissProt: Q16612 Human

SwissProt: Q07475 Mouse

SwissProt: Q80Z34 Rat

Unigene: 36053 Human

Unigene: 694860 Human

Unigene: 728773 Human

Unigene: 407415 Mouse

Unigene: 8180 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

P311 protein 还称:PTZ17 (pentylenetetrazd117)又称:增生性瘢痕相关蛋白。该蛋白与烧伤后瘢痕增生修复有关

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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