Anti-SLC25A12/FITC Conjugated抗体
产品名称: Anti-SLC25A12/FITC Conjugated抗体
英文名称: Anti-SLC25A12/FITC
产品编号: YB--11953R-FITC
产品价格: null
产品产地: 中国/美国
品牌商标: Ybscience
更新时间: 2023-08-17T10:29:50
使用范围: 科研使用
上海钰博生物科技有限公司
- 联系人 : 陈环环
- 地址 : 上海市沪闵路6088号龙之梦大厦8楼806室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 183****2235
- 传真 : 021-60514606
- 邮箱 : shybio@126.com
Anti-SLC25A12/FITC Conjugated抗体
产品编号 | YB-11953R-FITC |
英文名称 | Anti-SLC25A12/FITC |
中文名称 | FITC标记的钙结合线粒体载体蛋白抗体 |
别 名 | AGC1; Araceli hiperlarga; ARALAR; ARALAR1; Calcium binding mitochondrial carrier superfamily member; Calcium-binding mitochondrial carrier protein Aralar1; CMC1_HUMAN; Mitochondrial aspartate glutamate carrier 1; SLC25A12; Solute carrier family 25 member 12; solute carrier family 25, member 12. |
规格价格 | 100ul/2980元 购买 大包装/询价 |
说 明 书 | 100ul |
研究领域 | 肿瘤 细胞生物 神经生物学 信号转导 细胞类型标志物 新陈代谢 |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Human, Mouse, Rat, Dog, Cow, Horse, |
产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 75kDa |
细胞定位 | 细胞膜 |
性 状 | Lyophilized or Liquid |
浓 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human SLC25A12/ARALAR |
亚 型 | IgG |
纯化方法 | affinity purified by Protein A |
储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
产品介绍 | background: Calcium signaling in mitochondria is important in order for it to function in response to a variety of extracellular stimuli. Signaling begins with Ca(2+) entry in mitochondria via the Ca(2+) uniporter followed by Ca(2+) activation of three dehydrogenases in the mitochondrial matrix. ARALAR, the neuronal Ca(2+)-binding mitochondrial aspartate-glutamate carrier, has Ca(2+) binding domains facing the extramitochondrial space and functions in the malate-aspartate NADH shuttle (MAS). ARALAR is encoded by the SLC25A12 gene and is expressed in brain and skeletal muscle. ARALAR is required for the synthesis of brain aspartate and N-acetylaspartatemay and plays a role in myelin formation. It is also essential for the transmission of small Ca(2+) signals to mitochondria via an increase in mitochondrial NADH. In addition, ARALAR is implicated in conferring susceptibility to schizophrenia. Function: Calcium-dependent mitochondrial aspartate and glutamate carrier. May have a function in the urea cycle. Subcellular Location: Mitochondrion inner membrane. Tissue Specificity: High levels in heart and skeletal muscle, low in brain and very low in kidney. DISEASE: Defects in SLC25A12 are the cause of aspartate-glutamate carrier 1 deficiency (AGC1D) [MIM:612949]; also called global cerebral hypomyelination. This syndrome consists of a child severe psychomotor retardation, hypotonia and hypomyelination of the central nervous system. Similarity: Belongs to the mitochondrial carrier family. Contains 4 EF-hand domains. Contains 3 Solcar repeats. Database links: Entrez Gene: 8604 Human Entrez Gene: 78830 Mouse Entrez Gene: 362145 Rat Omim: 603667 Human SwissProt: O75746 Human SwissProt: Q8BH59 Mouse Unigene: 470608 Human Unigene: 30928 Mouse Unigene: 483680 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |