Anti-RRAGA + RRAGB/FITC Conjugated抗体上海钰博生物科技有限公司

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产品名称: Anti-RRAGA + RRAGB/FITC Conjugated抗体
英文名称: Anti-RRAGA + RRAGB/FITC
抗体货号: YB--10731R-FITC
产品规格: 20ul/50ul/100ul/200ul
级    别: , 分析纯, 见说明书
产品产地: 中国/美国
品牌商标: Ybscience
价    格: 2980元
抗原: KLH conjugated synthetic peptide derived from human RRAGA and RRAGB
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: Human, Mouse, Rat, Dog, Pig, Horse, Sheep,
见说明书conjugate:见说明书
Isotype:见说明书
应用范围: 科研使用
更新时间: 2019/7/2 9:20:00
详细资料:  实验方法技术资料
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诚信指数:2562点
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使用范围:仅限科研使用,不能应用于临床
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上海钰博生物科技有限公司
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产品详细描述

 Anti-RRAGA + RRAGB/FITC Conjugated抗体

产品编号 YB-10731R-FITC
英文名称 Anti-RRAGA + RRAGB/FITC
中文名称 FITC标记的RAS相关GTP结合蛋白A抗体
别    名 FIP1; RAGA; FIP-1; RRAGB; Adenovirus E3 14.7 kDa-interacting protein 1; Rag A; RAg B; RagA; RAGB; Ras related GTP binding protein A; RRAGA_HUMAN; Ras-related GTP binding A; GTP-binding protein ragB; Rag B; RagB; Ras-related GTP-binding protein B; RRAGB; RRAGB_HUMAN..  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  细胞生物  免疫学  染色质和核信号  信号转导  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Horse, Sheep, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 37kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human RRAGA and RRAGB
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Involved in the RCC1/Ran-GTPase pathway. RRAGA may play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity. biquitously expressed with highest levels of expression in skeletal muscle, heart, and brain.

Function:
Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity. Required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death. 

Subunit:
Binds GTP. Can occur as a homodimer or as a heterodimer with RRAGC or RRAGD in a sequence-independent manner; heterodimerization stabilizes PPAG proteins. In complex with RRAGC, but not with RRAGB, interacts with RPTOR. The GTP-bound form of RRAGA interacts with NOL8. Interacts with adenovirus E3 14.7 kDa protein.

Subcellular Location:
Cytoplasm. Nucleus. Lysosome. Note=Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state. Colocalizes in vivo with adenovirus E3-14.7K mainly to the cytoplasm especially near the nuclear membrane and in discrete foci on or near the plasma membrane. 

Tissue Specificity:
Ubiquitously expressed with highest levels of expression in skeletal muscle, heart, and brain. 

Similarity:
Belongs to the GTR/RAG GTP-binding protein family. 

Database links:

Entrez Gene: 10670 Human

Entrez Gene: 68441 Mouse

Entrez Gene: 117044 Rat

Omim: 612194 Human

SwissProt: Q7L523 Human

SwissProt: Q80X95 Mouse

SwissProt: Q63486 Rat

Unigene: 702275 Human

Unigene: 31178 Mouse

Unigene: 2816 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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