Anti-phospho-nNOS (Ser847) /FITC Conjugated抗体上海钰博生物科技有限公司

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产品名称: Anti-phospho-nNOS (Ser847) /FITC Conjugated抗体
英文名称: Anti-phospho-nNOS (Ser847) /FITC
抗体货号: YB--19303R-FITC
产品规格: 20ul/50ul/100ul/200ul
级    别: , 分析纯, 见说明书
产品产地: 中国/美国
品牌商标: Ybscience
价    格: 2980元
抗原: KLH conjugated Synthesised phosphopeptide derived from mouse nNOS around the phosphorylation site of Ser847
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: Human, Mouse, Rat, Chicken, Pig, Horse, Rabbit, Xenopus laevis
见说明书conjugate:见说明书
Isotype:见说明书
应用范围: 科研使用
更新时间: 2019/7/12 9:17:00
详细资料:  实验方法技术资料
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诚信指数:2562点
了解更多:进入公司展台
使用范围:仅限科研使用,不能应用于临床
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产品详细描述

 Anti-phospho-nNOS (Ser847) /FITC Conjugated抗体

产品编号 YB-19303R-FITC
英文名称 Anti-phospho-nNOS (Ser847) /FITC
中文名称 FITC标记的***酸化一氧化氮合成酶-1(神经型)抗体
别    名 nNOS (neuronal) (phospho S847); p-nNOS (neuronal) (phospho S847); nNOS (phospho S847); p-nNOS (phospho S847); nNOS (neuronal) (phospho S852)(human); 2310005C01Rik; bNOS; Constitutive NOS; EC 1.14.13.39; IHPS 1; IHPS1; N NOS; N-NOS; NC NOS; NC-NOS; neuronal Nitric Oxide Synthase; Neuronal NOS; Nitric oxide synthase , neuronal, included; Nitric oxide synthase 1 (neuronal); Nitric oxide synthase 1; Nitric oxide synthase brain; Nitric oxide synthase, brain; Nitric oxide synthase, penile neuronal, included; nNOS; NO; NOS 1; NOS; NOS type I; NOS-I; NOS1; NOS1_MOUSE; Peptidyl-cysteine S-nitrosylase NOS1.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
产品类型 ***酸化抗体 
研究领域 肿瘤  细胞生物  神经生物学  信号转导  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Pig, Horse, Rabbit, Xenopus laevis
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 160kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from mouse nNOS around the phosphorylation site of Ser847
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous system, nitric oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. This protein is ubiquitously expressed, with high level of expression in skeletal muscle. Multiple transcript variants that differ in the 5' UTR have been described for this gene but the full-length nature of these transcripts is not known. Additionally, alternatively spliced transcript variants encoding different isoforms (some testis-specific) have been found for this gene.[provided by RefSeq, Feb 2011] 

Function:
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR.

Subcellular Location:
Cell membrane, sarcolemma. Cell projection, dendritic spine. In skeletal muscle, it is localized beneath the sarcolemma of fast-twitch muscle fiber by associating with the dystrophin glycoprotein complex. In neurons, enriched in dendritic spines.

Tissue Specificity:
Isoform 1 is ubiquitously expressed: detected in skeletal muscle and brain, also in testis, lung and kidney, and at low levels in heart, adrenal gland and retina. Not detected in the platelets. Isoform 3 is expressed only in testis. Isoform 4 is detected in testis, skeletal muscle, lung, and kidney, at low levels in the brain, but not in the heart and adrenal gland.

Post-translational modifications:
Ubiquitinated; mediated by STUB1/CHIP in the presence of Hsp70 and Hsp40 (in vitro).

Similarity:
Belongs to the NOS family.
Contains 1 FAD-binding FR-type domain.
Contains 1 flavodoxin-like domain.
Contains 1 PDZ (DHR) domain.

Database links:

Entrez Gene: 4842 Human

Entrez Gene: 18125 Mouse

Entrez Gene: 100009243 Rabbit

Entrez Gene: 24598 Rat

Entrez Gene: 60658 Zebrafish

Omim: 163731 Human

SwissProt: P29475 Human

SwissProt: Q9Z0J4 Mouse

SwissProt: O19132 Rabbit

SwissProt: P29476 Rat

Unigene: 654410 Human

Unigene: 684465 Human

Unigene: 684466 Human

Unigene: 684467 Human

Unigene: 442195 Mouse

Unigene: 44249 Mouse

Unigene: 10573 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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