Anti-phospho-ITGB4 (Thr1526/Thr1530)/FITC Conjugated抗体-抗体-抗体-生物在线
Anti-phospho-ITGB4 (Thr1526/Thr1530)/FITC Conjugated抗体

Anti-phospho-ITGB4 (Thr1526/Thr1530)/FITC Conjugated抗体

商家询价

产品名称: Anti-phospho-ITGB4 (Thr1526/Thr1530)/FITC Conjugated抗体

英文名称: Anti-phospho-ITGB4 (Thr1526/Thr1530)/FITC

产品编号: YB--18359R-FITC

产品价格: null

产品产地: 中国/美国

品牌商标: Ybscience

更新时间: 2023-08-17T10:29:50

使用范围: 科研使用

上海钰博生物科技有限公司
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 Anti-phospho-ITGB4 (Thr1526/Thr1530)/FITC Conjugated抗体

产品编号 YB-18359R-FITC
英文名称 Anti-phospho-ITGB4 (Thr1526/Thr1530)/FITC
中文名称 FITC标记的磷酸化整合素β4抗体
别    名 Integrin beta 4 (phospho T1526); p-Integrin beta 4 (phospho T1526); ITGB4 (phospho T1526); ITGB4 (phospho Thr1526); p-ITGB4(Thr1526); human Integrin beta 4 (phospho T1530); human Integrin beta 4 (phospho Thr1530); Integrin beta 4;Integrin beta4; ITGB4; ITGB-4; CD 104; CD104; CD104 antigen; GP150; Integrin beta-4; ITB4_HUMAN; ITG B4; ITGB 4; ITGB4.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 信号转导  细胞凋亡  细胞表面分子  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Pig, Guinea Pig, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 197kDa
性    状 Lyophilized or Liquid
浓    度 2mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from mouse phospho-ITGB4 (Thr1526/Thr1530)
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Function:
Integrin alpha-6/beta-4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility.

Subunit:
Heterodimer of an alpha and a beta subunit. Beta-4 associates with alpha-6. Interacts (via cytoplasmic region) with COL17A1 (via cytoplasmic region). Interacts (via cytoplasmic region) with DST isoform 3 (via N-terminus). Interacts (via cytoplasmic domain) with DST (via N-terminus). Interacts with RAC1.

Subcellular Location:
Membrane; Single-pass type I membrane protein. Cell junction, hemidesmosome. Note=Colocalizes with DST at the leading edge of migrating keratinocytes.

Tissue Specificity:
Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoform beta-4D is also expressed in colon and placenta. Isoform beta-4E is also expressed in epidermis, lung, duodenum, heart, spleen and stomach.

DISEASE:
Defects in ITGB4 are a cause of epidermolysis bullosa letalis with pyloric atresia (EB-PA) [MIM:226730]; also known as junctional epidermolysis bullosa with pyloric atresia (PA-JEB) or aplasia cutis congenita with gastrointestinal atresia. EB-PA is an autosomal recessive, frequently lethal, epidermolysis bullosa with variable involvement of skin, nails, mucosa, and with variable effects on the digestive system. It is characterized by mucocutaneous fragility, aplasia cutis congenita, and gastrointestinal atresia, which most commonly affects the pylorus. Pyloric atresia is a primary manifestation rather than a scarring process secondary to epidermolysis bullosa.
Defects in ITGB4 are a cause of generalized atrophic benign epidermolysis bullosa (GABEB) [MIM:226650]. GABEB is a non-lethal, adult form of junctional epidermolysis bullosa characterized by life-long blistering of the skin, associated with hair and tooth abnormalities.

Similarity:
Belongs to the integrin beta chain family.
Contains 1 Calx-beta domain.
Contains 4 fibronectin type-III domains.
Contains 1 PSI domain.
Contains 1 VWFA domain.

Database links:

Entrez Gene: 3691 Human

Entrez Gene: 192897 Mouse

Entrez Gene: 25724 Rat

Omim: 147557 Human

SwissProt: P16144 Human

SwissProt: A2A863 Mouse

SwissProt: Q64632 Rat

Unigene: 632226 Human

Unigene: 213873 Mouse

Unigene: 198908 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications