Anti-PAF1 Polyclonal Antibody北京索莱宝科技有限公司

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产品名称: Anti-PAF1 Polyclonal Antibody
英文名称: Anti-PAF1 Polyclonal Antibody
抗体货号: K107432P
产品规格: 50ul/100ul
级    别: ,
产品产地: 北京
品牌商标: Solarbio
价    格: 900/50ul;1600/100ul元
抗原: A synthetic peptide of human PAF1
抗原来源: 
抗体来源: Rabbit
适用物种: Human Mouse Rat
应用范围: WB IHC
更新时间: 2019/9/6 15:47:00
详细资料:  实验方法技术资料
浏览人数:17
诚信指数:1315点
了解更多:进入公司展台
使用范围:仅限科研使用,不能应用于临床
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北京索莱宝科技有限公司
地址:
北京市通州区马驹桥镇联东U谷景盛南四街15号85A三层
邮编:
101102
电话:
18435223305
传真:
010-56371281
联系人:
郭倩
所在区域:
北京·北京
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公司展台:
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产品详细描述

 

Anti-PAF1 Polyclonal Antibody、

品牌:Solarbio | 货号:K107432P
商品货号:商品品牌:规格基本售价:选择规格
K107432P-50ulSolarbio50ul960.00元
K107432P-100ulSolarbio100ul1600.00元
英文名称Anti-PAF1 Polyclonal Antibody
宿主Rabbit
别名F23149_1;PD2;
RNA polymerase II-associated factor 1 homolog
应用WB IHC
稀释比例WB 1:8000-12000. IHC 1:25-100.
交叉反应Human Mouse Rat
蛋白分子量55/60kDa
保存Store at -20°C. Avoid freeze / thaw cycles.
储存液Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法Affinity purification
亚型IgG
免疫原A synthetic peptide of human PAF1
Subcellular
Locations
Nucleus
Swiss ProtQ8N7H5
克隆类型Polyclonal Antibody
背景资料Component of the PAF1 complex (PAF1C) which has
multiple functions during transcription by RNA polymerase
II and is implicated in regulation of development and
maintenance of embryonic stem cell pluripotency. PAF1C
associates with RNA polymerase II through interaction with
POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-
phosphorylated forms and is involved in transcriptional
elongation, acting both indepentently and synergistically
with TCEA1 and in cooperation with the DSIF complex and
HTATSF1. PAF1C is required for transcription of Hox and
Wnt target genes. PAF1C is involved in hematopoiesis and
stimulates transcriptional activity of KMT2A/MLL1; it
promotes leukemogenesis through association with
KMT2A/MLL1-rearranged oncoproteins, such as
KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL.
PAF1C is involved in histone modifications such as
ubiquitination of histone H2B and methylation on histone
H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3
ubiquitin-protein ligase complex and the E2 enzyme UBE2A
or UBE2B to chromatin which mediate monoubiquitination
of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-
mediated H2B ubiquitination is proposed to be coupled to
transcription. PAF1C is involved in mRNA 3' end formation
probably through association with cleavage and poly(A)
factors. In case of infection by influenza A strain H3N2,
PAF1C associates with viral NS1 protein, thereby regulating
gene transcription. Connects PAF1C with the RNF20/40 E3
ubiquitin-protein ligase complex. Involved in
polyadenylation of mRNA precursors. Has oncogenic
activity in vivo and in vitro.

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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