Anti-ALYREF Polyclonal Antibody北京索莱宝科技有限公司

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性能参数

产品名称: Anti-ALYREF Polyclonal Antibody
英文名称: Anti-ALYREF Polyclonal Antibody
抗体货号: K107490P
产品规格: 50ul/100ul
级    别: , ,
产品产地: 北京
品牌商标: Solarbio
价    格: 900/50ul;1600/100ul元
抗原: A synthetic peptide of human ALYREF
抗原来源: 
抗体来源: Rabbit
适用物种: Human Mouse Rat
应用范围: WB IHC
更新时间: 2019/9/9 8:53:00
详细资料:  实验方法技术资料
浏览人数:6
诚信指数:1279点
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使用范围:仅限科研使用,不能应用于临床
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供应商联系卡

北京索莱宝科技有限公司
地址:
北京市通州区马驹桥镇联东U谷景盛南四街15号85A三层
邮编:
101102
电话:
18435223305
传真:
010-56371281
联系人:
郭倩
所在区域:
北京·北京
邮件:
公司展台:
在线QQ:
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产品详细描述

 

Anti-ALYREF Polyclonal Antibody  

品牌:Solarbio | 货号:K107490P
商品货号:商品品牌:规格基本售价:选择规格
K107481P-50ulSolarbio50ul960.00元
K107481P-100ulSolarbio100ul1600.00元
英文名称Anti-ALYREF Polyclonal Antibody
宿主Rabbit
别名ALY;ALY/REF;BEF;REF;THOC4;THO complex subunit 4
应用WB IHC
稀释比例WB 1:5000-8000. IHC 1:100-300.
交叉反应Human Mouse Rat
蛋白分子量27kDa
保存Store at -20°C. Avoid freeze / thaw cycles.
储存液Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法Affinity purification
亚型IgG
免疫原A synthetic peptide of human ALYREF
Subcellular
Locations
Nucleus Cytoplasm
Swiss ProtQ86V81
克隆类型Polyclonal Antibody
背景资料Export adapter involved in nuclear export of spliced and
unspliced mRNA. Binds mRNA which is thought to be
transferred to the NXF1-NXT1 heterodimer for export
(TAP/NFX1 pathway). Component of the TREX complex
which is thought to couple mRNA transcription,
processing and nuclear export, and specifically associates
with spliced mRNA and not with unspliced pre-mRNA.
TREX is recruited to spliced mRNAs by a transcription-
independent mechanism, binds to mRNA upstream of the
exon-junction complex (EJC) and is recruited in a splicing-
and cap-dependent manner to a region near the 5' end of
the mRNA where it functions in mRNA export to the
cytoplasm. TREX recruitment occurs via an interaction
between ALYREF/THOC4 and the cap-binding protein
NCBP1. The TREX complex is essential for the export of
Kaposi's sarcoma-associated herpesvirus (KSHV) intronless
mRNAs and infectious virus production; ALYREF/THOC4
mediates the recruitment of the TREX complex to the
intronless viral mRNA. Required for TREX complex
assembly and for linking DDX39B to the cap-binding
complex (CBC). In conjunction with THOC5 functions in
NXF1-NXT1 mediated nuclear export of HSP70 mRNA;
both proteins enhance the RNA binding activity of NXF1
and are required for NXF1 localization to the nuclear rim.
Involved in the nuclear export of intronless mRNA;
proposed to be recruited to intronless mRNA by ATP-
bound DDX39B. Involved in transcription elongation and
genome stability.


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