Anti-PAK4 Polyclonal Antibody北京索莱宝科技有限公司

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产品名称: Anti-PAK4 Polyclonal Antibody
英文名称: Anti-PAK4 Polyclonal Antibody
抗体货号: K108662P
产品规格: 
产品产地: 北京
品牌商标: Solarbio
价    格: 询价
抗原来源: 
抗体来源: Rabbit
适用物种: Human Mouse
应用范围: WB IHC
更新时间: 2021/1/15 15:13:00
详细资料:  实验方法技术资料
浏览人数:27
诚信指数:1451点
了解更多:进入公司展台
使用范围:仅限科研使用,不能应用于临床
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生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

供应商联系卡

北京索莱宝科技有限公司
地址:
北京市通州区马驹桥镇联东U谷景盛南四街15号85A三层
邮编:
101102
电话:
010-50973129
传真:
010-56371281
联系人:
张净花
所在区域:
北京·北京
邮件:
公司展台:
在线QQ:
我是405465416,请问我有什么可以帮到您呢?
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产品详细描述

Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN. 

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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