产品简介
英文名称
Anti-RIPK1 Polyclonal Antibody
宿主
Rabbit
别名
RIP;RIP-1;RIP1;receptor interacting serine/threonine kinase 1
稀释比例
IHC 1:25-100.
蛋白分子量
70/75kDa
Gene ID
8737
保存
Store at -20°C. Avoid freeze / thaw cycles.
储存液
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法
Affinity purification
亚型
IgG
免疫原
A synthetic peptide of Human RIPK1
亚细胞定位
Cytoplasm Cell membrane
Swiss Prot
Q13546
背景资料
Serine-threonine kinase which transduces inflammatory and cell-death signals following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex.
Public Immunogen Range
385-435/671aa
克隆类型
Polyclonal Antibody
交叉反应
Human
应用
IHC
规格
50ul 100ul
备注：
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these methods.
实验图