Anti-IRF3 Polyclonal Antibody北京索莱宝科技有限公司

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产品名称: Anti-IRF3 Polyclonal Antibody
英文名称: Anti-IRF3 Polyclonal Antibody
抗体货号: K108672P
产品规格: 
产品产地: 北京
品牌商标: Solarbio
价    格: 询价
抗原来源: 
抗体来源: Rabbit
适用物种: Human Mouse
应用范围: WB IHC
更新时间: 2021/1/15 15:13:00
详细资料:  实验方法技术资料
浏览人数:27
诚信指数:1451点
了解更多:进入公司展台
使用范围:仅限科研使用,不能应用于临床
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生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

供应商联系卡

北京索莱宝科技有限公司
地址:
北京市通州区马驹桥镇联东U谷景盛南四街15号85A三层
邮编:
101102
电话:
010-50973129
传真:
010-56371281
联系人:
张净花
所在区域:
北京·北京
邮件:
公司展台:
在线QQ:
我是405465416,请问我有什么可以帮到您呢?
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产品详细描述

Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages. 

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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