产品简介
英文名称
Anti-ATG4C Polyclonal Antibody
宿主
Rabbit
别名
APG4-C;APG4C;AUTL1;AUTL3;cysteine protease ATG4C
稀释比例
WB 1:2000-5000. IHC 1:50-200.
蛋白分子量
52kDa
Gene ID
84938
保存
Store at -20°C. Avoid freeze / thaw cycles.
储存液
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法
Affinity purification
亚型
IgG
免疫原
A synthetic peptide of Human ATG4C
亚细胞定位
Cytoplasm
Swiss Prot
Q96DT6
背景资料
Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Is not essential for autophagy development under normal conditions but is required for a proper autophagic response under stressful conditions such as prolonged starvation. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.
Public Immunogen Range
405-455/458aa
克隆类型
Polyclonal Antibody
交叉反应
Human
应用
WB IHC
规格
50ul 100ul
备注：
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these methods.
实验图
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