产品简介
英文名称
Anti-CALCOCO2 Polyclonal Antibody
宿主
Rabbit
别名
NDP52
稀释比例
WB 1:2000-5000. IHC 1:25-100.
蛋白分子量
43/47/52kDa
Gene ID
10241
保存
Store at -20°C. Avoid freeze / thaw cycles.
储存液
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法
Affinity purification
亚型
IgG
免疫原
A synthetic peptide of Human CALCOCO2
亚细胞定位
Cytoplasm
Swiss Prot
Q13137
背景资料
Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy. Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation. Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C. May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion.
Public Immunogen Range
75-125/446aa
克隆类型
Polyclonal Antibody
交叉反应
Human
应用
WB IHC
规格
50ul 100ul
备注：
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these methods.
实验图
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