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Cergutuzumab amunaleukin
CAS No. : 1509916-03-3
MCE 国际站：Cergutuzumab amunaleukin
产品活性：Cergutuzumab amunaleukin (CEA-IL2v) 是一种基于癌胚抗原 (CEA) 靶向 IL-2 变体的免疫细胞因子。Cergutuzumab amunaleukin 具有免疫刺激和抗肿瘤活性。
研究领域：Immunology/Inflammation
作用靶点：Interleukin Related
In Vitro: Cergutuzumab amunaleukin comprises a single IL-2 variant (IL2v) moiety with abolished CD25 binding, fused to the C-terminus of a high affinity, bivalent CEA-specific antibody devoid of Fc-mediated effector functions. Its molecular design aims to avoid preferential activation of regulatory T-cells vs. immune effector cells by removing CD25 binding.
 
The activation of NK cells by Cergutuzumab amunaleukin (CEA-IL2v; 0.001-1000 nM) translated into increased killing of the CEA-positive colon cancer cell line LS180 accompanied by increased release of Granzyme B, IFNγ and RANTES and upregulation of CD25 and CD69 on NK cells.
In Vivo: In tumor-free mice, a strong expansion of peripheral CD8+ T and NK cells after treatment with 0.5 and 2 mg/kg Cergutuzumab amunaleukin (CEA-IL2v;  i.v.; once) is observed.
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