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Concizumab
CAS No. : 1312299-39-0
MCE 国际站:Concizumab
产品活性:Concizumab 是一种 抗 TFPI 单克隆抗体 (IgG4 型),可与 TFPI 的 Kunitz 型蛋白酶抑制剂 (KPI) 2 结构域结合,从而阻断该结构域与 FXa 活性位点的相互作用。Concizumab 可用于血友病的研究。
研究领域:Others
作用靶点:Others
In Vitro: Concizumab increases thrombin peak in a concentration- dependent manner.
In Vivo: Concizumab (i.v./s.c.) blocks the TFPI interaction with the active site of FXa in cynomolgus monkeys.
1.19 Pharmacokinetic parameters after intravenous or subcutaneous administration of Concizumab to cynomolgus monkeys.
Parameter Unit Estimate %RSE CLL mL/h/kg 0.14 6.1 V1 mL/kg 33 34 V2 mL/kg 33 - Q mL/h/kg 0.12 16 F % 93 7.7 Vmax g/h/kg 11 17 Km g/mL 0.54 52 t1/2(abs) h 72 32
CLL: the linear part of the clearance.
V1: the volume of the central compartment.
V2: the volume of the peripheral compartment.
Vmax: the maximum amount of anti-TFPI cleared per time unit via binding to TFPI.
Km: the concentration at which the target mediated elimination rate is 50% of the maximum value (Vmax).
T1/2(abs): the absorption half-life, describing the rate of absorption after sc administration.
%RSE: residual standard error.相关产品:Antitumor agent-67 | Catechin 7-O-β-D-glucopyranoside | Carbobenzoxyproline | ATR-IN-9 | TBTDC | Peucenin 7-O-methyl ether | 6-Hydroxy-4-methylcoumarin | Acridine Orange base | AMT-NHS | Nylidrin hydrochloride | C13-112-tri-tail | (4S)-1-Boc-4-fluoro-D-proline | D-(+)-Fucose | OVA Peptide (323-339) | Secretin (swine) | Bletilloside A | Transcriptional Intermediary Factor 2 (TIF2) (740-753) | Pep-1 (uncapped) | Aspochalasin M | Dihydrofuran-3(2H)-one | BPK-29 hydrochloride | pppApG | MEIS-IN-2 | 2′-O-Methyl-8-methyl guanosine | Altertoxin I | Lithospermoside | Acitazanolast | FLAG peptide | [Des-Tyr1]-Met-Enkephalin | α-Carotene
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