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Adintrevimab
CAS No. : 2516243-54-0
MCE 国际站：Adintrevimab
产品活性：Adintrevimab (ADG 20) 是一种人 IgG1 单克隆 SARS-CoV (SARS-CoV) 抗体。Adintrevimab 抑制 SARS-CoV-2 变体和其他具有大流行潜力的 SARS 样冠状病毒。
研究领域：Anti-infection
作用靶点：SARS-CoV
In Vitro: The crystallizable fragment (Fc) region of Adintrevimab has a modification to extend its half-life. Adintrevimab binds to a distinct epitope in the receptor-binding domain of the spike glycoprotein of SARS-CoV-2 that partially overlaps the angiotensin-converting enzyme 2 binding site and is highly conserved among sarbecoviruses. In vitro, Adintrevimab has demonstrated potent neutralizing activity against most variants and sublineages of SARS-CoV-2 (including Alpha, Beta, Gamma, and Delta) as well as other SARS-like viruses. Adintrevimab displays reduced in vitro activity against Omicron BA.1/BA.1.1 and lacks activity against BA.2, BA.3, BA.4, and BA.5.
In Vivo: Adintrevimab (9.25, 55, 333, or 2,000μg; i.p.; once) provids protection against SARS-CoV-2/WA1/2020 infection in a dose-dependent manner.

Adintrevimab (5-25mg/kg; i.v.; once) provids protection against SARS-CoV-2/WA1/2020 infection in a dose-dependent manner.
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