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Denileukin diftitox
CAS No. : 173146-27-5
MCE 国际站:Denileukin diftitox
产品活性:Denileukin diftitox (DAB 389IL-2) 是一种白喉毒素 (DT) 相关的白细胞介素 2 (IL-2) 融合蛋白毒素,可耗尽表达高亲和力形式的 IL-2 受体 (IL-2R)、CD25。Denileukin diftitox 与表达 IL-2R 的细胞结合并通过白喉毒素片段的内化抑制蛋白质合成。
作用靶点:Interleukin Related
In Vitro: Denileukin diftitox (DAB 389IL-2) is a 3-domain fusion protein toxin comprised of the diphtheria toxin (DT) catalytic domain, the diphtheria toxin (DT) membrane translocation domain, and human IL-2 substituted in place of the native diphtheria toxin (DT)-receptor binding domain.
Denileukin diftitox (1-1000 pM; HUT 102/6TG cells) increases the cytotoxic potency of the insertion mutants by approximately 17-fold for high-affinity IL-2-receptor-bearing cell lines.In Vivo: Denileukin diftitox (DAB 389IL-2; 35 μg/kg; i.p.; C57BL/6 mice with infected H37Rv) inhibits mycobacterial replication and reduces Treg and myeloid-derived suppressor cells (MDSCs) frequencies in mouse model.
Denileukin diftitox (2.5 or 3 μg/head; i.v.) has antitumor activity and inhibits tumor growth in mouse model.相关产品:RCGD423 | Vunakizumab | Tagraxofusp | Dupilumab | IL-17A modulator-2 | Daclizumab | PNRI-299 | Ginsenoside F3 | Broussonin E | Clerodendrin | Vudalimab | 1,4-Dicaffeoylquinic acid | Cetrelimab | Hydrangenol | Mulberroside A | Oxelumab | Sirukumab | Y13g | Ginsenoside Rc | BIRT 377 | Ixekizumab | IL-17 modulator 3 | IL-17A modulator-3 | Armillarisin A | Ustekinumab | Kansuinine B | VGX-1027 | RO2959 hydrochloride | Cendakimab | Koaburaside
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Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
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