BioLegend公司LEAF系列抗体上海新睿生物科技有限公司

性能参数

产品名称: BioLegend公司LEAF系列抗体
英文名称: BioLegend公司LEAF系列抗体
抗体货号: 
产品规格: 抗体
产品产地: 美国
品牌商标: Biolegend
价    格: 询价
抗原来源: 
抗体来源: 
适用物种: 
应用范围: 
更新时间: 2019/5/24 13:37:00
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产品详细描述

BioLegend公司LEAF系列抗体

什么是LEAF抗体?

LEAFLow EndotoxinAzide Free的简写,表示该系列产品经过无菌检测和内毒素质控检测(<0.01 ng/µL),并且不含叠氮化物。

LEAF抗体的优点?

内毒素在体内可以引起一系列反应,包括各种炎症反应,低血压,白细胞数异常,血管内血凝结,休克甚至致死。体外实验表明,内毒素可以与CD14以及其他一些受体反应,诱导单核细胞以及巨噬细胞释放细胞因子,触发补体系统,促进B细胞分裂。

叠氮化物由于可以抑制革兰氏阴性菌生长,因此常作为防腐剂,但同时可以阻断线粒体的电转运系统,对大多数的有机体有毒性。在体内,叠氮化物和*化物相似,对细胞色素氧化酶和其它酶有抑制作用,并能使体内氧合血红蛋白的形成受阻,有显著的降压作用;同时对眼和皮肤有刺激性。因此,内毒素和叠氮化物会给实验带来不可控因素,降低实验的特异性,影响结果的准确性。

BioLegend公司LEAF系列纯化抗体有效降低或消除了二者对实验的影响,为功能性研究提供最准确的结果

Biolegend为您提供:

200多种LEAF抗体;

可以根据客户的需求将纯化的抗体制成LEAF标准的产品;

对一部分LEAF抗体提供1mg的大包装,以方便客户实验。

 

BioLegend LEAF系列产品目录

Specificity

Clone

Biofunction

Application References

Mouse CD1d (CD1.1, Ly-38)

1B1

Blocking1

1. Fischer, K., et al., 2004. Proc. Natl. Acad. Sci. USA 101:10685.PubMed

Mouse CD2 (LFA-2)

RM2-5

Blocking1,2

1. Nakamura, T., et al., 1990. J. Immunol. 145:3628. PubMed 

2. Ayroldi, E., et al., 1997. Blood 89:3717. PubMed

Mouse CD2 (LFA-2)

RM2-5

Costimulation1

1. Cibotti, R., et al., 1997. Immunity 6:245. PubMed

Mouse CD3

17A2

Activation1

1. Miescher, G.C., et al., 1989. Immunol. Lett. 23:113. PubMed

Mouse CD3

17A2

Depletion1

1. Mysliwietz, J., et al., 1992. Blood 80:2661. PubMed

Mouse CD3ε (T3, C3e)

145-2C11

Inhibition1

1. Leo, O., et al., 1987. PNAS 84:1374. PubMed

Mouse CD3ε (T3, C3e)

145-2C11

Apoptosis1

1. Henrickson, M. et al., 1995. Transplantation 60:828.PubMed

Mouse CD3ε (T3, C3e)

145-2C11

Depletion1

1. Han, W.R., et al., 1999. Transpl. Immunol. 7:207.PubMed

Mouse CD3ε (T3, C3e)

145-2C11

Activation1

1. Wang, W., et al., 2007. J. Immunol. 178:4885.PubMed

Mouse CD4 (L3T4, T4)

GK1.5

Blocking1

1. Dialynas, D.P., et al., 1983. J. Immunol. 131:2445.PubMed

Mouse CD4 (L3T4, T4)

GK1.5

Costimulation1

1. Wu, L., et al., 1991. J. Exp. Med. 174:1617.PubMed

Mouse CD4 (L3T4, T4)

GK1.5

Depletion1

1. Israelski, D.M., et al., 1989. J. Immunol. 142:954. PubMed

Mouse CD4 (L3T4, T4)

RM4-5

Depletion1

1. Kruisbeek, A.M., 1991. Curr. Protocols Immunol. pp. 411-415.PubMed

Mouse CD4 (L3T4, T4)

RM4-5

Blocking1

1. Kruisbeek, A.M., 1991. Curr. Protocols Immunol. pp. 411-415. PubMed

Mouse CD8a (T8, Ly-2)

53-6.7

Depletion1

1. Hathcock, K.S., 1991. Curr. Protocols Immunol. pp. 341 - 3.4.3.

Mouse CD8a (T8, Ly-2)

53-6.7

Blocking1,2

1. Takahashi, K., et al., 1992. PNAS 89:5557. PubMed 

2. Ledbetter, J.A., et al., 1981. J. Exp. Med. 153:1503.PubMed

Mouse CD11a (LFA-1 α chain,

M17/4

Blocking1,2

1. Sanchez-Madrid, F., et al., 1982. Cell Immunol. 73:1.PubMed 

integrin αL)

2. Kuhlman, P., et al., 1991. J. Immunol. 146:1773. PubMed

Mouse CD11b (Mac-1, integrin αM)

M1/70

Blocking1

1. Springer, T.A., et al., 1982. Immunol. Rev. 68:171.PubMed

Mouse CD14

Sa14-2

Blocking1

1. Hajishengallis, G., et al., 2006. Infect Immun. 74:5658.PubMed

Mouse CD16/32 (FcγR III)

93

Blocking1,2

1. Oliver, A. M., et al., 1999. Hybridoma 18:113. PubMed 

2. Clements, J. L., et al., 2006. J. Immunol. 177:905.PubMed

Mouse CD18 (β2 integrin)

M18/2

Blocking1,2

1. Zahalka, M.A., et al., 1993. J. Immunol. 150:4466.PubMed 

2. Ishida, Y., et al., 1994. Cell. Immunol. 155:414. PubMed

Mouse CD18 (β2 integrin)

M18/2

Stimulation1

1. Driessens, M.H.E., et al., 1996. J. Leukoc. Biol. 60:758.PubMed

Mouse CD19 (B4)

6D5

Induction/Protection of Apoptosis1

1. Celikkaya, H., et al., 2007. Hybridoma 26 (2):55.PubMed

Mouse CD21/CD35 (CR2/CR1)

7.00E+09

Activation1

1. Kozono, Y., et al., 1998. J. Immunol. 160:1565.PubMed

Mouse CD24 (HAS)

M1/69

Induction1

1. Springer, T., et al., 1978. Eur. J. Immunol. 8:539.  PubMed

Mouse CD25 (IL-2R α)

3C7

Blocking1,2

1. Ortega, R.G., et al., 1984. J. Immunol. 133:1970. PubMed

2. Moreau, JL., et al., 1987. Eur. J. Immunol. 17:929. PubMed

Mouse CD25 (IL-2R α)

PC61

Blocking1,2

1. Ceredig, R., et al., 1985. Nature 314:98.PubMed

2. Lowenthal, J.W., et al., 1985. J. Immunol. 135:3988.PubMed

Mouse CD25 (IL-2R α)

PC61

Depletion1,2

1. Takahashi, T., et al., 2000. J. Exp. Med. 192:303.PubMed 

2. Lei, T.C., et al., 2005. Blood 105:4865. PubMed

Mouse CD27

LG.3A10

Blocking1

1. Gravestein, L.A., et al., 1996. J. Exp. Med. 194:675.PubMed

Mouse CD28 (TP44)

37.51

Blocking1,2

1. Masten, B.J., et al., 1997. Am. J. Respir. Cell Mol. Biol. 16:335. PubMed

2. Nishio, M., et al., 1996. J. Immunol. 157:4347.PubMed

Mouse CD28 (TP44)

37.51

Costimulation1,2

1. Gross, J.A., et al., 1992. J. Immunol. 149:380.PubMed

2. Cibotti, R., et al., 1997. Immunity 6:245. PubMed

Mouse CD28 (TP44)

E18

Costimulation1

1. Dennehy, K.M., et al., 2006. J. Immunol. 176:5725. PubMed

Mouse/Rat CD29 (Integrin β1)

HMß1-1

Blocking1,2

1. Noto, K., et al., 1995. Int. Immunol. 7: 835. PubMed

2. Ridger, V.C., et al., 2001. J. Immunol. 166:3484.PubMed

Mouse CD30 (Ki-1, TNFRSF8)

mCD30.1

Costimulation1

1. Bowen, M.A., et al., 1996. J. Immunol. 156:442.PubMed

Mouse CD31 (PECAM-1)

390

Blocking1,2

1. Baldwin, H.S., et al., 1994. Development 120:2539.PubMed

2. DeLisser, H.M., et al., 1997. Am. J. Pathol. 151:671. PubMed

Mouse CD31 (PECAM-1)

MEC13.3

Blocking1,2

1. Vecchi, A, et al., 1994. Eur. J. Cell Biol. 63:247.PubMed

2. Christofidou-Solomidou, M., et al., 1997. J. Immunol. 158:4872. PubMed

Mouse CD40 (gp39R, TNFRSF5)

1C10

Costimulation1,2

1. Ferlin, W. G., et al., 1998. Eur. J. Immunol. 28:525.PubMed

2. Heath, A., et al., 1994. Eur. J. Immunol. 24:1828.PubMed

Mouse CD40 (gp39R, TNFRSF5)

1C10

Blocking1,2

1. Peláez, B., et al., 2001.  J. Immunol. 166:6608.PubMed

2. Zhang, P., et al., 2007.  J. Immunol. 178:474. PubMed

Mouse CD40 (gp39R, TNFRSF5)

HM40-3

Blocking1

1. Kawano, T., et al., 1997. Science 278:1626.  PubMed

Mouse CD40 (gp39R, TNFRSF5)

HM40-3

Costimulation1,2

1. Kaneko, Y., et al., 1996. Eur. J. Immunol. 26:3061.PubMed

2. Akiba, H., et al., 1999. J. Immunol. 162:7058. PubMed

Mouse/Human CD44 (pgp-1)

IM7

Blocking1,2

1. Camp, R.L., et al., 1993. J. Exp. Med. 178:497.PubMed

2. Weiss, J.M., et al., 1997. J. Cell Biol. 137:1137.PubMed

Mouse CD45

30-F11

Complement-dependent cytotoxicity1,2

1. Ledbetter, J.A., et al., 1979. Immunol. Rev. 47:63.PubMed

2. Seaman, W.E., 1983. J. Immunol. 130:1713.PubMed

Mouse CD45R (B220)

RA3-6B2

Activation1,2

1. George, A., et al., 1994. J. Immunol. 152:1014.PubMed

2. Domiati-Saad, R., et al., 1993. J. Immunol. 151:5936.PubMed

Mouse CD48 (Blast-1)

HM48-1

Costimulation1,2

1. Kato, K., et al., 1992. J. Exp. Med. 176:1241.PubMed

2. Qin, L., et al., 1994. J. Exp. Med. 179:341.PubMed

Mouse CD48 (Blast-1)

HM48-1

Blocking1

1. Kato, K., et al., 1992. J. Exp. Med. 176:1241. .PubMed

Mouse CD48 (Blast-1)

HM48-1

Inhibition1

1. Qin, L., et al., 1994. J. Exp. Med. 179:341. PubMed

Mouse CD49b (α2 integrin)

HMα2

Blocking1,2

1. Miyake, S., et al., 1994. Eur. J. Immunol. 24:2000. PubMed

2. Arase, H., et al., 2001. J. Immunol. 167:1141.PubMed

Mouse CD49d (VLA-4, α4 integrin)

R1-2

Blocking1,2

1. Holzmann, B., et al., 1989. Cell 56:37.PubMed 

2. Ferguson, T.A., et al., 1993. J. Immunol. 150:1172. PubMed

Mouse CD49d (VLA-4, α4 integrin)

9C10(MFR4.B)

Blocking1,2

1. Kinashi, T., et al., 1994. Blood Cells 20:25.PubMed

2. Halvorson, M.J., et al., 1995. J. Immunol. 155:4567.PubMed

Mouse CD49e (VLA-5α, α integrin)

5H10-27

Blocking1,2

1. Kinashi, T., et al., 1994. Blood Cells 20:25. PubMed

(MFR5)

2. Halvorson, M.J., et al., 1995. J. Immunol. 155:4567. .PubMed

Mouse CD49e (VLA-5α, α integrin)

5H10-27

Costimulation1

1. Rich, S., et al., 1996. J. Immunol. 157:2916.PubMed 

(MFR5)

Mouse/Rat CD49e (VLA-5α, α5 integrin)

HMα5-1

Blocking1,2

1. Yasuda, M., et al., 1995. Int. Immunol. 7:251.PubMed

2. Noto, K., et al., 1995. Int. Immunol. 7:835.PubMed

Mouse/Human CD49f

GoH3

Blocking1,2

1. Georas, S. N., et al., 1993. Blood 82:2872. PubMed 

2. Nakamura, K., et al., 1997. Biochem. Biophys. Res. Commun. 235:524. PubMed

Mouse CD51 (Integrin αV )

H9.2B8

Blocking1,2

1. Maxfield, S.R., et al., 1989. J. Exp. Med. 169: 2173.PubMed,

2. Piali, L., et al., 1995. J. Cell Biol. 130: 451. PubMed

Mouse CD51 (Integrin αV )

RMV-7

Blocking1,2

1. Takahashi, K., et al., 1990. J. Immunol. 145:4371.PubMed

2. Narumiya, S., et al., 1994. Int. Immunol. 6:139. PubMed

Mouse CD54 (ICAM-1)

YN1/1.7.4

Blocking1,2

1. Horley, K.J., et al., 1989. EMBO J. 8:2889. PubMed

2. Burns, A.R., et al., 1994. J. Immunol. 153:3189. PubMed

Mouse/Rat CD61 (β3 integrin)

2C9.G2 (HMß3-1)

Blocking1,2

1. Piali, L., et al., 1995. J. Cell Biol. 130:451. PubMed

2. Ashkar, S., et al., 2000. Science 287:860. PubMed

Mouse/Rat CD61 (β3 integrin)

2C9.G2 (HMß3-1)

Activation1

1. Moulder, K., et al., 1991. J. Exp. Med. 173:343.PubMed

Mouse CD62L (L-selectin)

MEL-14

Blocking1,2

1. Gallatin, W.M., et al., 1983. Nature 304:30. PubMed

2. Siegelman, M.H., et al., 1990. Cell 61:611.PubMed

Mouse CD70 (CD27R)

FR70

Blocking1,2

1. Akiba, H., H., et al., 1999. J. Immunol. 162:7058.PubMed 

2. Takeda, K., et al., 2000. J. Immunol. 164:1741.PubMed

Mouse CD80 (B7-1)

16-10A1

Blocking1,2

1. Razi-Wolf, Z., et al., 1992. PNAS 89:4210. PubMed

2. Hathcock, K.S., et al., 1994. J. Exp. Med. 180:631.  PubMed

Mouse/Rat CD81 (TAPA-1)

Eat-2

Induction1

1. Maecker, H. T., et al., 2000. Hybridoma 19:15.PubMed

Mouse/Rat CD81 (TAPA-1)

Eat-2

Costimulation1

1. Maecker, H. T., et al., 2000. Hybridoma 19:15. PubMed

Mouse/Rat CD81 (TAPA-1)

Eat-2

Activation1

1. Clark, K. L., et al., 2001. J. Immunol. 167:5115.PubMed

Mouse CD86 (B7-2)

GL-1

Blocking1,2

1. Hathcock, K.S., et al., 1993. Science 262:905. PubMed

2. Inaba, K., M., et al., 1994. J. Exp. Med. 180:1849. PubMed

Mouse CD86 (B7-2)

PO3

Blocking1,2

1. Nakajima, A., et al., 1995. Eur. J. Immunol. 25:3060. PubMed 

2. Saito, K., et al., 1998. J. Immunol. 160:4225.PubMed

Mouse CD86 (B7-2)

PO3

Stimulation1

1. Kasprowicz, D.J., et al., 2000. J. Immunol. 165:680. PubMed

Mouse CD90 (Thy-1)

G7

Activation1,2

1. Gunter, K.C., et al., 1984. J. Exp. Med. 159:716. PubMed

2. Tentori, L., et al., 1988. J. Immunol. 140: 1089.PubMed

Mouse CD90 (Thy-1)

G7

Apoptosis1,2

1. Hueber, A.-O., et al., 1994. J. Exp. Med. 179: 785. PubMed

2. Ucker, D.S., et al., 1992. J. Immunol. 149: 1583. PubMed

Mouse CD90.2 (Thy-1.2)

30-H12

Depletion1,2

1. Hathcock, K.S. 1991. Curr. Protocols Immunol. 341 PubMed

2. Seaman, W.E., 1983. J. Immunol. 130:1713. PubMed

Mouse CD90.2 (Thy-1.2)

30-H12

Costimulation1,2

1. Nakashima, I., et al., 1991. J. Immunol. 147:1153.PubMed

2. Nakashima, I., et al., 1993. J. Immunol. 151:3511.PubMed

Mouse CD102 (ICAM-2)

3C4 (MIC2/4)

Blocking1

1. Xu, H., et al., 1996. J. Immunol. 156:4909. PubMed

2. Gerwin, N., et al., 1999. Immunity 10:9.PubMed

Mouse CD103

2.00E+07

Activation1

1. LeFrancois, L., et. al., 1994. Eur. J. Immunol. 24:635.PubMed

Mouse CD106 (VCAM-1)

429 (MVCAM.A)

Blocking1,2

1. Kinashi, T., et al., 1994. Blood Cells 20:25. PubMed

2. Meunier, M-C., et al., 2005. Nature Medicine 11:1222. PubMed

Mouse CD120a (TNF R Type I/p55)

55R-170

Blocking1

1. Sheehan, K. C., et al., 1995. J. Exp. Med. 181:607.PubMed

Mouse CD120a (TNF R Type I/p55)

55R-593

Blocking1

1. Sheehan, K. C., et al., 1995. J. Exp. Med. 181:607. PubMed

Mouse CD120b (TNF R Type II/p75)

TR75-32.4

Blocking1

1. Sheehan, K. C., et al., 1995. J. Exp. Med. 181:607. PubMed

Mouse CD120b (TNF R Type II/p75)

TR75-54.7

Blocking1

1. Sheehan, K. C., et al., 1995. J. Exp. Med. 181:607. PubMed

Mouse CD121a (IL-1 R, Type I/p80)

JAMA-147

Blocking1

1. Rogers, H., K., et al., 1992. PNAS 89:1011.PubMed

Mouse CD122 (IL-2R β)

TM-β1

Block1

1. Tanaka, T., et al., 1991. J. Immunol. 147:2222.PubMed

Mouse CD122 (IL-2R β)

TM-β1

Depletion1

1. Tanaka, T., et al., 1993. J. Exp. Med. 178:1103. PubMed

Mouse/Rat CD126 (IL-6 R α chain)

D7715A7

Blocking1,2

1. Coulie, P. G., et al., 1990. Curr. Top. Microbiol. Immunol. 166:43. PubMed

2. Vink, A., et al., 1990. J. Exp. Med. 172:997. PubMed

Mouse CDw137 (4-1BB Ligand)

TKS-1

Blocking1

1. Akiba, H., et al., 2000. J. Exp. Med. 191:375.PubMed

Mouse CD137

17B5

Blocking1

1. Zheng, G., et al., 2004. J. Immunol. 173:2428.PubMed

(IL-3R β, common β chain)

Mouse CD150 (SLAM)

TC15-12F12.2

Costimulation1

1. Castro, A.G., et al., 1999. J. Immunol. 163:5860. PubMed

Mouse CD150 (SLAM)

TC15-12F12.2

Inhibition1

1. Jordan, M. A., et al., 2007. J. Immunol. 178:1618.PubMed

Mouse CD152 (CTLA-4)

9H10

Costimulation1

1. Krummel, M.F., et al., 1995. J. Exp. Med. 182:459.PubMed

Mouse CD152 (CTLA-4)

9H10

Blocking1,2

1. Krummel, M.F., et al., 1995. J. Exp. Med. 182:459. PubMed

2. Krummel, M.F., et al., 1996. Int. Immunol. 8:519.  PubMed

Mouse CD152 (CTLA-4)

UC10-4B9

Blocking1,2

1. Walunas, T.L., et al., 1994. Immunity 1:405. PubMed

2. McCoy, K., et al., 1997. J. Exp. Med. 186:183. PubMed

Mouse CD153 (CD30L)

RM153

Blocking1,2

1. Akiba, H., et al., 2000. J. Exp. Med. 191:375. .PubMed

2. Zeiser, R.,  et al., 2007. Blood 109:2225.PubMed

Mouse CD154 (CD40L)

MR1

Blocking1,2

1. Noelle, R.J., et al., 1992. PNAS 89:6550. PubMed

2. Roy, M., et al., 1995. Eur. J. Immunol. 25:596.  PubMed

Mouse CD178 (FasL)

MFL3

Blocking apoptosis1,2

1. Fuller, C.L., et al., 1999. J. Immunol. 162:6337. PubMed

2. Kayagaki, N., et al., 1997. PNAS 94:3914. PubMed

Mouse/Rat CD178 (FasL)

MFL4

Blocking1,2

1. Trinité, B., et al., 2000. J. Immunol. 165:4202. PubMed

2. Kayagaki, N., et al., 1997. PNAS 94:3914. PubMed

Mouse CD178.1 (FasL)

Kay-10

Blocking1,2

1. Kayagaki, N., et al., 1997. PNAS 94:3914. PubMed

2. Hattori, K., et al., 1998. Blood 91:4051. PubMed

Mouse CD180 (RP105)

RP/14

Activation1,2

1. Miyake, K., et al., 1994. J. Exp. Med. 180 :1217. PubMed

2. Chan, V.W.F., et al., 1998. J. Exp. Med. 188:93.  PubMed

Mouse CD180 (RP105)

RP/14

Induction/Protection of Apoptosis1, 2

1. Miyake, K., et al., 1994. J. Exp. Med. 180:1217. PubMed

2. Yamashita, Y., et al., 1996. J. Exp. Med. 184:113.PubMed

Mouse CD183 (CXCR3)

CXCR3-173

Blocking1

1. Uppaluri, R., et al. 2008. Transplantation. 86:137. PubMed

Mouse CD210 (IL-10 R)

1B1.3a

Blocking1,2

1. Iwashiro, M., et al., 2001. PNAS 98:9226. PubMed 

2. Vicari, A.P., et al., 2002. J. Exp. Med. 196:541. PubMed

Mouse CD223 (LAG-3)

C9B7W

Inhibition, not blocking1,2

1. Workman C.J., et al., 2002. Eur. Immunol. 32:2255. PubMed

2. Workman, C.J. et al., 2005. J. Immunol. 174:688.PubMed

Mouse CD252 (OX40 Ligand)

RM134L

Blocking1,2

1. Akiba, H., et al., 1999. J. Immunol. 162: 7058. PubMed 

2. Akiba, H., et al., 2000. J. Exp. Med. 191:375. PubMed

Mouse CD253 (TRAIL)

N2B2

Blocking1,2

1. Kayagaki, N., et al., 1999. J. Immunol. 163:1906. PubMed

2. Sato, K., et al., 2005. J. Immunol. 174:4025.PubMed

Mouse CD254 (TRANCE, RANKL)

IK22/5

Blocking1,2

1. Miyahira, Y., et al., 2003. J. Immunol. 171:6344. PubMed

2. Kamijo, S., et al., 2006. Biochem. Biophys. Res. Commun. 347:124.PubMed

Mouse CD255 (TWEAK)

MTW-1

Blocking1

1. Nakayama, M., et al., 2003. Biochem. Biophys. Res. Commun. 306:819.PubMed

Mouse CD262 (DR5, TRAIL-R2)

MD5-1

Cytotoxicity1,2

1. Takeda, K., et al.,2004. J. Exp. Med. 199:437. PubMed

2. Sato, K., et al., 2005. J. Immunol. 174:4025. PubMed

Mouse CD273 (PD-L2, PDL2, B7DC)

TY25

Blocking1,2

1. Ansari, M.J.I., et al., 2003. J. Exp. Med. 198:63. PubMed

2. Yamazaki, T., et al., 2005. J. Immunol. 175:1586. PubMed

Mouse CD274 (B7-H1, PD-L2)

10F.9G2

Blocking1

1. Maier H., et al., 2007. J Immunol. 178:2714.PubMed

Mouse CD275

HK5.3

Blocking1,2

1. Iwai, H., et al., 2003. J. Immunol. 171:2848. PubMed

(B7-RP1 , ICOSL, B7H2)

2. Kohyama, M., et al., 2004. Proc. Natl. Acad. Sci. USA 101:4192    PubMed

Mouse CD278 (ICOS)

C398.4A

Costimulation1,2

1. Redoglia, V., et al. 1996. Eur. J. Immunol. 26:2781.  PubMed

2. Arimura, Y., et al. 2004. J. Biol. Chem. 279:11408.PubMed

Mouse CD278 (ICOS)

7E.17G9

Blocking1,2

1. Akbari, O., et al., 2002. Nat. Med. 8:1024.  PubMed

2. Harada, H., et al., 2003. J. Clin. Invest. 112:234. PubMed

Mouse CD279 (PD-1 )

RMP1-14

Blocking1

1. Matsumoto, K., et al., 2004. J. Immunol. 172:2530. PubMed

Mouse CD284

MTS510

Blocking1

1. Akashi, S., et al., 2000. J. Immunol. 164:3471. PubMed

(Toll-like Receptor 4, TLR4, )

Mouse CD314 (NKG2D)

A10

Costimulation1,2

1. Gilfillan S, et al., 2002. Nat. Immunol. 3:1150. PubMed

2. Ho, E.L., et al., 2002. J. Immunol. 169:3667. PubMed

Mouse CD314 (NKG2D)

C7

Blocking1

1. Gilfillan, S., et al., 2002. Nat. Immunol. 3:1150.  PubMed

Mouse CD314 (NKG2D)

C7

Redirected lysis1

1. Ho, E.L., et al., 2002. J. Immunol. 169:3667. PubMed

Mouse FR4

TH6

Cytotoxicity1

1. Yamaguchi, T., et al.: 2007. Immunity 27 (1):145 PubMed

Mouse GITR

YGITR 765

Stimulation1

1. Tone, M., et al., 2003. PNAS 100(25):15059. PubMed

Mouse GITR

DTA-1

,

Inhibition1

1. Shimizu, J., et al., 2002. Nat. Immunol. 3:135. PubMed

Mouse H-2L

28-14-8

Blocking1

1. Ozato, K., et al., 1980. J. Immunol. 125:2473. PubMed

Mouse I-A

25-9-17

Activation1

1. Ozato, K., et al., 1981. J. Immunol. 126:317. PubMed

Mouse I-A/I-E

M5/114.15.2

Blocking1,2

1. Shi, Y., et al., 1998. J. Exp. Med. 187:367. PubMed

2. Kim, A., et al., 2004. Exp. and Mol. Med. 36:428. PubMed

Mouse IFNAR-1

MAR1-5A3

Blocking1

1. Sheehan, K.C., et al., 2006. J. Interferon Cytokine Res. 26:804.  PubMed

Mouse Integrin β7

FIB27

Blocking1

1. Andrew, D. P., et al., 1994. J. Immunol. 153:3847. PubMed

Mouse Integrin β7

FIB504

Blocking1,2

1. Andrew, D. P., et al., 1994. J. Immunol. 153:3847.PubMed

2. Rott, L. S., et al., 1996. J. Immunol. 156:3727. PubMed

Mouse LPAM-1 (Integrin α4β7) 

DATK32

Blocking1,2

1. Andrew, D. P. et al., 1994. J. Immunol. 153:3847. PubMed

2. Berlin-Rufenach , C. et al., 1999. J. Exp. Med.  189:1467.PubMed

Mouse Ly-6G/Ly-6C (Gr-1)

RB6-8C5

Depletion1,2

1. Stoppacciaro, A., et al., 1993. J. Exp. Med. 178:151. PubMed

2. Czuprynski, C.J., et al., 1994. J. Immunol. 152:1836.  PubMed

Mouse MAdCAM-1

MECA-367

Blocking1,2

1. Streeter, P. R., et al., 1988. Nature 331:41. PubMed

2. Bargatze, R. F., et al., 1995. Immunity 3:99. PubMed

Mouse MD-1

MD-113

Blocking1

1. Nagai, Y., et al., 2002. Blood 99 :1699. PubMed

Mouse NK-1.1

PK136

Depletion1,2

1. Senan, C.L., et al., 1989. J. Immunol. 142:1847. PubMed

2. Koo, G.C., et al., 1986. J. Immunol. 137:3742. PubMed

Mouse NK-1.1

PK136

Stimulation1

1. Karlhofer, F.M., et al., 1991. J. Immunol. 146:3662.  PubMed

Mouse NK-1.1

PK136

Blocking1

1. Kung, S.K., et al., 1999. J. Immunol. 162:5876. PubMed

Mouse TCR-β chain

H57-597

Stimulation1,2

1. Kruisbeek, A., et al., 1991. Curr. Protocols Immunol. pp. 3.12.1            

2. Davenport, C., et al., 1995. J. Immunol. 155:3742.PubMed

Mouse TCR-β chain

H57-597

Depletion1,2

1. Drobyski, W., et al., 1996. Blood 87:5355. PubMed

2. van der Heyde, H.C., et al., 1995. J. Immunol. 154:3985. PubMed

Mouse γδ TCR

UC7-13D5

Stimulation1

1. Bluestone, J.A., et al., 1991. Immunol. Rev. 120:5.  3.12.1 – 3.12.14.  PubMed

Mouse γδ TCR

UC7-13D5

Depletion1,2

1. Hiromatsu, K., et al., 1992. J. Exp. Med. 175:49. PubMed

2. van der Heyde, H.C., et al., 1995. J. Immunol. 154:3985. PubMed

Rat CD8a

G28

Blocking1

1. Torres-Nagel, N. et al., 1992. Eur. J. Immunol. 22:2841. PubMed

Rat CD8b

341

Blocking1

1. Torres-Nagel, N., et al., 1992. Eur. J. Immunol. 22:2841. PubMed

Rat CD8b

341

Macrophage stimulation1,2

1. Hirji, N., et al., 1997. J. Immunol. 158:1833. PubMed 

2. Hirji, N., et al., 1998. J. Immunol. 160:6004. PubMed

Rat CD28

JJ319

Costimulation1,2

1. Tacke, M., et al., 1995. J. Immunol. 154:5121. PubMed

2. Tacke, M., et al., 1997. Eur. J. Immunol. 27:239. PubMed

Rat CD49d

MRα4-1

Activation1

1. Yasuda, M., et al., 1995. Int. Immunol. 7:251. PubMed

Rat CD49d

MRα4-1

Inhibition1,2

1. Yasuda, M., et al., 1995. Int. Immunol. 7:251. PubMed 

2. Martinez-Lemus L., et al., 2005 Am J Physiol Heart Circ Physiol 289: H322-H329. PubMed

Rat CD80

3H5

Blocking1

1. Maeda, K., et al., 1997. Int. Immunol. 9:993. PubMed

Rat CD86

24F

Blocking1

1. Maeda, K., et al., 1997. Int. Immunol. 9:993. PubMed 

Rat CD126

D7715A7

Blocking1,2

1. Coulie, P. G., et al., 1990. Curr. Top. Microbiol. Immunol. 166:43. PubMed

2. Vink, A., et al., 1990. J. Exp. Med. 172:997. PubMed

Rat CD178 (FasL)

MFL4

Blocking1,2

1. Trinité, B., et al., 2000. J. Immunol. 165:4202. PubMed

2. Kayagaki, N., et al., 1997. PNAS 94:3914. PubMed

Rat OX-40 Ligand

ATM-2

Blocking1,2

1. Satake, Y., et al., 2000. Biochem. Biophys. Res. Commun. 270:1041. PubMed

2. Yuan, X., et al., 2003. J. Immunol. 170:2949. PubMed

Rat αβ TCR

R73

Activation1,2

1. Hunig, T. et al., 1989. J. Exp. Med. 169:73. PubMed

2. Mitnacht, R., et al., 1995. Eur. J. Immunol. 25:328. PubMed

Rat αβ TCR

R73

Depletion1,2

1. Yoshino, S. et al., 1992.  J. Exp. Med. 175:907. PubMed

2. Mitnacht, R., et al., 1995. Eur. J. Immunol. 25:328. PubMed

Human CD2

RPA-2.10

Blocking1

1. Aversa, G., et al., 1987. Transplant. Proc. 19:277. PubMed

Human CD2

TS1/8

Blocking1

1. Hughes, C.C., et al., 1996. J. Biol. Chem. 271:5369. PubMed

Human CD3

HIT3a

Activation1,2

1. Sedelies, K. A., et al., 2004. J. Biol. Chem. 279:26581. PubMed

2. Rivollier, A., et al., 2004. Blood 104:4029. PubMed

Human CD3

OKT3

Activation1,2

1. Hibino, S., et al., 1998. Biochem. Biophys. Res. Comm. 250:119. PubMed

2. Schwab, R., et al., 1985. J. Immunol. 135:1714. PubMed

Human CD3

UCHT1

T cell activation1,2

1. Graves, J., et al., 1991. J. Immunol. 146:2102. PubMed

2. Lafont, V., et al., 2000. J. Biol. Chem. 275:19282. PubMed

Human CD4

OKT4

Blocking1

1. Finnegan, C.M., et al., 2007. J. Virol. 81: 5294. PubMed

Human CD4

RPA-T4

Blocking1,2

1. Knapp, W., et al., 1989. Leucocyte Typing IV. Oxford University Press. New York.

2. Moir, S., et al., 1999. J. Virol. 73:7972. PubMed

Human CD8a

RPA-T8

Costimulation1

1. Magidovich, E., et al., 2007. Proc. Natl. Acad. Sci. USA 104: 13022. PubMed

Human CD11a

HI111

Blocking1

1. Béchard, D., et al., 2001. J. Immunol. 167:3099. PubMed

Human CD11b

ICRF44

Blocking1,2

1. Rezzonico, R., et al., 2001. Blood 97:2932. PubMed

2. Marsik, C., et al., 2003. Shock 20:493. PubMed

Human CD11b (activated)

CBRM1/5

Blocking1,2

1. Diamond, M., et al., 1993. J. Cell Biol. 120:545. PubMed

2. Oxvig, C. et al., 1999. PNAS 96:2215. PubMed

Human CD11c

3.9

Inhibition1,2

1. Zaffran, Y., et al., 1998. Infect. Immun. 66:4541. PubMed

2. Baniyash, M., et al., 1987 J. Immunol. 138:2999. PubMed

Human CD13

WM15

Blocking1,2

1. Saiki, I., et al., 1993. Int J Cancer. 54:137. PubMed 

2. Rosenzwajg, M., et al., 2000. Blood 95:453. PubMed

Human CD14

M5E2

Blocking1

1. Power, C. P., et al., 2004. J. Immunol. 173:5229. PubMed

Human CD16

3G8

Blocking1,2

1. Tamm, A., et al., 1996. J. Immunol. 157:1576. PubMed

2. Holl, V., et al., 2004. J. Immunol. 173:6274. PubMed

Human CD16

3G8

Stimulation1,2

1. Hoshino, S., et al., 1991. Blood 78:3232. PubMed

2. Dall’Ozzo, S. et al., 2004. Cancer Res.  64:4664. PubMed

Human CD18

TS1/18

Inhibition1,2

1. Van Epps, D. E., et al., 1989. J. Immunol. 143:3207. PubMed

2. Meerschaert, J., et al., 1994. J. Immunol. 152:1915. PubMed

Human CD28

CD28.2

Costimulation1,2

1. Marti, F., et al., 2001. J. Immunol.166:197. PubMed

2. Jeong, S-H., et al., 2004. J Virol. 78:6995. PubMed

Human CD29

TS2/16

Activation1,2

1. Sanchez-Aparicio, P., et al., 1994. J. Cell Biol. 126:271. PubMed

2. Porter, J.C. and Hogg, N., 1997. J. Cell Biol. 138:1437. PubMed

Human CD31

WM59

Blocking1

1. Wu, X-W., et al., 1997. Arterioscler Thromb and Vasc Biol 17:3154. PubMed

Human CD33

WM53

Costimulation1

1. Garnache-Ottou, F., et al., 2005. Blood 105:1256. PubMed

Human CD40

G28.5

B cell activation1

1. Ledbetter, J., et al., 1987. J. Immunol. 138:788. PubMed

Human CD40

HB14

Costimulation1

1. Pound, J.D., et al., 1999. Int. Immunol. 11:11. PubMed

2. Schlossman, S., et al., Eds. 1995. Leucocyte Typing V. Oxford University Press. New York.

Human CD42b

HIP1

Blocking1

1. Takahashi, R., et al., 1999. Blood 93:1951. PubMed

Human CD46

MEM-258

Blocking1,2

1. Sirena, D. et al., 2004. J. Virol. 78:4454. PubMed

2. Fleischli, C.  et al., 2007. J. Gen. Virol. 88:2925. PubMed

Human CD49b

AK-7

Blocking1,2

1. Halasz, P. et al., 2005.  Cell. Immunol.  236:179. PubMed

2. Coulson, B. et al., 1997. PNAS 94:5389. PubMed

Human CD49d

9F10

Costimulation1,2

1. Jeong, S-H., et al., 2004. J. Virol. 78:6995. PubMed

2. Vogel, T. U., et al., 2002. J. Immunol. 169:4511. PubMed

Human CD49e

NKI-SAM-1

Blocking1,2

1. Kim, S., et al., 2000. Am. J. Path 156:1345. PubMed

2. Rehn, M., et al., 2001. PNAS 98:1024. PubMed

Human/Mouse CD49f

GoH3

Blocking1,2

1. Georas, S. N., et al., 1993. Blood 82:2872. PubMed

2. Nakamura, K., et al., 1997. Biochem. Biophys. Res. Commun. 235:524. PubMed

Human CD51

NKI-M9

Blocking1

1. Grzeszkiewicz, T., et al., 2001 J. Biol. Chem. 276:21943. PubMed

Human CD51/61

23C6

Blocking1

1. Takahashi, R., et al., 1999. Blood 93:1951. PubMed

Human CD54

HCD54

Blocking1

1. Personal communication.

Human CD62L

DREG-56

Blocking1,2

1. Kishimoto, T., et al., 1990. PNAS 87:2244. PubMed

2. Jutila, M., et al., 2002. J. Immunol. 169:1768. PubMed

Human CD62P (P-Selectin)

AK4

Blocking1,2

1. Skinner, M., et al., 1991. J. Biol. Chem. 266:5371. PubMed

2. McCarty, O.J., et al., 2000. Blood 96:1789. PubMed

Human CD80

2D10

Blocking1,2

1. Ridge, J.P., et al., 1998. Nature 393:474. PubMed

2. Dilioglou, S., et al., 2003. Exp. Mol. Pathol. 75:217. PubMed

Human CD84

CD84.1.21

Activation1

1. Martin, M., et al., 2001. J. Immunol. 167: 3668. PubMed

2. Sayós, J., et al., 2001. Blood 97: 3867. PubMed

Human CD86

IT2.2

Blocking1,2

1. Dieu, M. 1998. J. Exp. Med. 188:373. PubMed

2. Jeannin, P. et al., 1999. J. Immunol. 162:2044. PubMed

Human CD95 (Fas)

EOS9.1

Apoptosis1,2

1. Desbarats, J., et al., 2003. Nat. Cell Biol. 5:118. PubMed

2. Inoue, M., et al., 2005. FEBS Lett. 579:604. PubMed

Human CD95 (Fas)

DX2

Apoptosis1,2

1. Cifone, M., et al., 1994. J. Exp. Med. 180:1547. PubMed

2. Bompard, G. et al., 2002. J. Biol. Chem. 49:47861. PubMed

Human CD117 (c-kit)

A3C6E2

Blocking1

1. Personal communication.

Human CDw119 (IFN-γ R α chain)

GIR-208

Blocking1

1. Sheehan, K., et al., 1988. J. Immunol. 140:4231. PubMed

2. Kishimoto, T., et al., Eds. 1997. Leucocyte Typing VI. Garland Publishing, Inc. London.

Human CD129 (IL-9 Receptor)

AH9R7

Blocking1,2

1. De Smedt, M., et al., 2000. J. Immunol. 164:1761. PubMed

2. Pilette, C., et al., 2002. J. Immunol. 168:4103. PubMed

Human CD137 (4-1BB)

4B4-1

Blocking1,2

1. Salih, H. R., et al., 2000. J. Immunol. 165:2903. PubMed

2. Kienzle, G., et al., 2000. Int. Immunol. 12:73.  PubMed

Human CD147

HIM6

Blocking1,2

1. Stonehouse, T.J., et al., 1999. Immunology.  96:35. PubMed

2. Woodhead, V.E., et al., 2000. Int. Immunol. 12:1051. PubMed

Human CD150 (SLAM)

A12 (7D4)

Costimulation1,2

1. Garcia, V., et al., 2001. J. Immunol. 167:5719. PubMed

2. Aversa, G., et al., 1997. J. Immunol. 158:4036. PubMed

Human CD154

24-31

Blocking1,2

1. Brams, P., et al., 2001. Int. Immunopharmacol. 1:277. PubMed

2. Rushworth, S.A., et al., 2002. Transplantation 73: 635. PubMed

Human CD178 (Fas-L)

NOK-1

Blocks Fas induced apoptosis1

1. Kayagaki, N., et al., 1995. J. Exp. Med. 182:1777. PubMed

Human CD180 (RP105)

MHR73-11

Stimulation1

1. Miura, Y., et al., 1998. Blood 92:2815. PubMed

Human CD184 (CXCR4)

12G5

Blocking1,2

1. Berndt, C., et al., 1998. Proc. Natl. Acad. Sci. USA 95:12556. PubMed

2. Ullrich, C. K., et al., 2000. Blood 96:1438. PubMed

Human CD206 (MMR)

15-2

Blocking1,2

1. Noorman, F., et al., 1997. J. Leukoc. Biol. 61:63. PubMed

2. Barrett-Bergshoeff, M., et al., 1997. Thromb Haemost. 77:718. PubMed

Human CD210 (IL-10 R)

3F9

Blocking1,2

1. Liu, Y., et al., 1997. J. Immunol. 158:604. PubMed

2. Levings, M.K., et al., 2005. Blood 105:1162. PubMed

Human CD218a (IL-18R alpha)

H44

Blocking1

1. Vermot-Desroches, C., et al., 2005. Cell Immunol. 236:101. PubMed

Human CD229 (Ly-9)

HLy-9.1.25

Activation1,2,3

1. de la Fuente, M. A., et al., 2001. Blood 97:3513. PubMed

2. Martin, M., et al., 2005. J. Immunol. 174: 5977. PubMed

3. Romero, X., et al., 2005. J. Immunol. 174:7033. PubMed

Human CD268 (BAFF-R, BAFFR)

11C1

Blocking1,2

1. Ng, L. G., et al., 2004. J. Immunol. 173:807. PubMed

2. Personal communication.

Human/Mouse/Rat CD278 (ICOS)

C398.4A

Costimulation1,2

1. Redoglia, V., et al., 1996. Eur. J. Immunol. 26:2781. PubMed

2. Arimura, Y., et al., 2004. J. Biol. Chem. 279:11408. PubMed

Human CD314 (NKG2D)

1D11

Activation1,2

1. Wu, J., et al., 2000. J. Exp. Med. 192:1059. PubMed

2. Groh, V., et al., 2001. Nat. Immunol. 2:255. PubMed

Human CD336 (NKp44)

P44-8

Blocking1,2

1. Stark, S., et al., 2005. J. Immunol. Methods 296:149. PubMed

2. Nolte-’t Hoen, E., et al., 2006. Blood 109:670. PubMed

Human CD337 (NKp30)

P30-15

Blocking1

1. Stark, S., et al., 2005. J. Immunol. Methods 296:149. PubMed

Human Fn14/TWEAK Receptor

ITEM-1

Apoptosis1,2

1. Nakayama, M., et al., 2003. J. Immunol. 170:341. PubMed

2. Felli, N., et al., 2005. J. Immunol. 175:1464. PubMed

Human Fn14/TWEAK Receptor

ITEM-1

Blocking1

1. Jin, L., et al., 2004. J. Invest. Dermatol. 122:1175. PubMed

Human HLA-A,B,C

W6/32

Activation1,2

1. Turco, M.C. et al., 1988. J. Immunol. 141:2275. PubMed

2. Geppert, T.D. et al., 1989. J. Immunol. 142:3763. PubMed

Human HLA-A,B,C

W6/32

Blocking1,2

1. De Felice, M. et al., 1990. Cell. Immunol. 126:420. PubMed

2. Nagano, M., et al., 2007. Blood 110:151. PubMed

Human HLA-DR

L243

Blocking1,2

1. Kalka-Moll, W. M., et al., 2002. J. Immunol. 169:1649. PubMed

2. Wang, R-F., et al., 1999. Science 284:1351. PubMed

Human/Mouse Integrin β7

FIB504

Blocking1,2

1. Andrew, D. P., et al., 1994. J. Immunol. 153:3847. PubMed

2. Rott, L. S., et al., 1996. J. Immunol. 156:3727. PubMed

Human KIR2DL2/L3 (NKAT2)

DX27

Restores NK cell cytotoxicity1,2

1. Bakker, A.B.H., et al., 1998. J. Immunol. 160:5239. PubMed

2. Valiante, N. M., et al., 1997. Immunity 7:739. PubMed

Human KIR3DL1 (NKB1)

DX9

Restores NK cell cytotoxicity1,2

1. Bakker, A.B.H., et al., 1998. J. Immunol. 160:5239. PubMed

2. Valiante, N. M., et al., 1997. Immunity 7:739. PubMed

Human Lymphotoxin b Receptor (LT-bR)

31G4D8

Induction of apoptosis1,2

1. Chen, M-C., et al., 2003. J. Biol. Chem. 278:16073. PubMed

2. Personal communication.

Human MICA/MICB

6D4

Blocking1,2

1. Groh, V., et al., 1999. Proc. Natl. Acad. Sci. USA. 96: 6879. PubMed

2. Groh, V., et al., 2001. Nat. Immunol. 2:255. PubMed

Human NTB-A (NTBA)

NT-7

Block1,2

1. Ward, J., et al., 2007. Blood 110:1207. PubMed

2. Personal communication.

Human TL1A

6.00E+06

Neutralization1

1. Yang, CR., et al., 2004. Cancer Res. 64:1122. PubMed

Human Toll-like Receptor 2 (TLR2)

TL2.1

Blocking1,2

1. Flo, T., et al., 2000. J. Immunol. 164:2064. PubMed

2. Sugawara, S., et al., 2001. Infect. Immun. 69:4951. PubMed

Human Toll-like Receptor 4 (TLR4)

HTA125

Blocking1,2

1. Wang, R., et al., 2003. Hybrid Hybridomics 22:357. PubMed

2. Wang, J.E., et al., Infect. Immun. 69:2402. PubMed

Human TRAIL

RIK-2

Blocking1,2 

1. Kayagaki, N., et al., 1999. J. Immunol. 162:2639. PubMed

2. Uno, K., et al., 2003. Blood 101: 3658. PubMed

Human TREM-1

TREM-26

Activation1

1. In-house testing.

Human TWEAK

CARL-1

Neutralization1,2

1. Nakayama, M., et al., 2000. J. Exp. Med. 192:1373. PubMed

2. Nakayama, M., et al., 2003. J. Immunol. 170:341. PubMed

Human TWEAK

CARL-2

Neutralization1

1. Nakayama, M., 2000. J. Exp. Med. 192:1373. PubMed

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