l Afadin,AF6蛋白抗体

产品编号HZ-16871R
英文名称l Afadin
中文名称AF6蛋白抗体
别 名AF 6; AF6; AFAD_HUMAN; Afadin; ALL1-fused gene from chromosome 6 protein; FLJ34371; MLLT 4; MLLT4; Myeloid/lymphoid or mixed lineage leukemia (trithorax homolog Drosophila) translocated to 4; Myeloid/lymphoid or mixed lineage leukemia translocated to 4; Protein AF 6; Protein Af-6; Protein AF6; RP3 431P23.3.
说 明 书0.1ml 0.2ml
研究领域细胞生物 神经生物学 信号转导 结合蛋白 细胞骨架
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Chicken, Zebrafish, Firefly,
l Afadin,AF6蛋白抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量68kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human l Afadin
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
l Afadin,AF6蛋白抗体PubMedPubMed
产品介绍background:
This gene encodes a multi-domain protein involved in signaling and organization of cell junctions during embryogenesis. It has also been identified as the fusion partner of acute lymphoblastic leukemia (ALL-1) gene, involved in acute myeloid leukemias with t(6;11)(q27;q23) translocation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, however, not all have been fully characterized.[provided by RefSeq, May 2011]

Function:
Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton.

Subcellular Location:
Cell junction > adherens junction. Not found at cell-matrix AJs.

DISEASE:
Note=A chromosomal aberration involving MLLT4 is associated with acute leukemias. Translocation t(6;11)(q27;q23) with MLL/HRX. The result is a rogue activator protein.

Similarity:
Contains 1 dilute domain.
Contains 1 FHA domain.
Contains 1 PDZ (DHR) domain.
Contains 2 Ras-associating domains.

Gene ID:
4301

l Afadin,AF6蛋白抗体Database links:
Entrez Gene: 421564 Chicken
Entrez Gene: 4301 Human
Entrez Gene: 17356 Mouse
Entrez Gene: 26955 Rat
Omim: 159559 Human
SwissProt: P55196 Human
SwissProt: Q9QZQ1 Mouse
SwissProt: O35889 Rat
Unigene: 614974 Human
Unigene: 644024 Human
Unigene: 708726 Human
Unigene: 728849 Human
Unigene: 59167 Mouse
Unigene: 58 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.