DOCK7,胞质分裂专一蛋白7抗体

产品编号HZ-11825R
英文名称DOCK7
中文名称胞质分裂专一蛋白7抗体
别 名dedicator of cytokinesis 7; Dedicator of cytokinesis protein 7; Gm430; KIAA1771 ; MGC189434; mKIAA1771; RP23 329P19.2; ZIR2; DOCK7_HUMAN.
说 明 书0.1ml 0.2ml
研究领域细胞生物 神经生物学 信号转导 G蛋白偶联受体 G蛋白信号
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, Sheep,
DOCK7,胞质分裂专一蛋白7抗体产品应用ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量242kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human DOCK7
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
DOCK7,胞质分裂专一蛋白7抗体PubMedPubMed
产品介绍background:
DOCK 7 is a 2,140 amino acid protein that localizes to developing axons and contains one DHR-1 domain and one DHR-2 domain. Expressed in a variety of tissues, DOCK 7 functions as a guanine nucleotide exchange factor (GEF) that specifically activates Rac 1 and Rac 3 by catalyzing the exchange of bound GDP for free GTP. Multiple isoforms of DOCK 7 exist due to alternative splicing events.

Function:
DOCK7 functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. It does not have a GEF activity for CDC42. It is required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization.

Subunit:
Interacts with TSC1. Interacts with nucleotide-free RAC1 and RAC3.

Subcellular Location:
Cell projection,

Tissue Specificity:
Widely expressed.

DOCK7,胞质分裂专一蛋白7抗体Similarity:
Belongs to the DOCK family.
Contains 1 DHR-1 domain.
Contains 1 DHR-2 domain.

Database links:
UniProtKB/Swiss-Prot: Q96N67.4

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.