ETV3,ETV3蛋白抗体

产品编号HZ-14647R
英文名称ETV3
中文名称ETV3蛋白抗体
别 名AI414410; bA110J1.4; ETS domain transcriptional repressor PE1; ETS family transcriptional repressor; ETS translocation variant 3; ets variant 3; ets variant gene 3; ets variant gene 3, ETS family transcriptional repressor; ETV3; ETV3_HUMAN; ME PE1; METS; Mitogenic Ets transcriptional suppressor; Oncogene PE1; PE 1; PE-1; PE1.
说 明 书0.1ml 0.2ml
研究领域细胞生物 转录调节因子 细胞分化 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Pig, Cow, Rabbit, Sheep,
ETV3,ETV3蛋白抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量57kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human ETV3
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
ETV3,ETV3蛋白抗体PubMedPubMed
产品介绍background:
ETV3 belongs to the ETS family of transcription factors and functions as a transcriptional repressor. ETS family members share a highly conserved DNA binding domain and play a role in growth factor pathways regulating proliferation and differentiation. PE-1 is ubiquitously expressed and localizes to the nucleus. Its expression can be induced by IL-10 via the STAT3 pathway suggesting that PE-1 contributes to the IL-10 downstream anti-inflammatory effects. During terminal cell differentiation, PE-1 plays a role in growth arrest by specifically repressing the target genes that are involved in Ras-dependent proliferation. The contributions of PE-1 to these anti-proliferative effects are heavily dependent on its interaction with Gemin3. Two PE-1 isoforms exist due to alternative splicing events.

Function:
Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity.

Subcellular Location:
Nucleus.

DISEASE:

ETV3,ETV3蛋白抗体Similarity:
Belongs to the ETS family.
Contains 1 ETS DNA-binding domain.

Gene ID:
2117

Database links:
Entrez Gene: 2117 Human
Entrez Gene: 27049 Mouse
Entrez Gene: 295297 Rat
Omim: 164873 Human
SwissProt: P41162 Human
SwissProt: Q8R4Z4 Mouse
Unigene: 105636 Human
Unigene: 219460 MouseUnigene: 225088

ETV3,ETV3蛋白抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.