Peroxiredoxin 2,硫氧还蛋白过氧化物酶Ⅱ/巯基抗氧化蛋白抗体

产品编号HZ-8300R
英文名称Peroxiredoxin 2
中文名称硫氧还蛋白过氧化物酶Ⅱ/巯基抗氧化蛋白抗体
别 名MGC4104; Natural killer cell enhancing factor B; Natural killer cell-enhancing factor B; Natural Killer Enhancing Factor B; NKEF B; NKEF-B; NKEFB; Peroxiredoxin-2; PRDX 2; PRDX2; PRDX2_HUMAN; PRP; PRX2; PRXII; TDPX1; Thiol Specific Antioxidant 1; Thiol specific antioxidant protein; Thiol-specific antioxidant protein; Thioredoxin Dependent Peroxide Reductase 1; Thioredoxin Peroxidase 1; Thioredoxin-dependent peroxide reductase 1; Torin; TPX1; TSA.
说 明 书0.1ml 0.2ml
研究领域细胞生物 免疫学 信号转导 细胞凋亡
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
Peroxiredoxin 2,硫氧还蛋白过氧化物酶Ⅱ/巯基抗氧化蛋白抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量22kDa
细胞定位细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Peroxiredoxin-2
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Peroxiredoxin 2,硫氧还蛋白过氧化物酶Ⅱ/巯基抗氧化蛋白抗体PubMedPubMed
产品介绍background:
Peroxiredoxin (Prx) is an antioxidant enzyme detoxifying reactive oxygen species and has a cysteine at the active site. Prx enzymes modulate various receptor signaling pathways and protect cells from oxidatively induced death. Peroxiredoxin 1 to 4 have two conserved Cys residues corresponding to Cys51 and Cys172 of mammalian Peroxiredoxin 1. The active site cysteine(Cys51) is oxidized to cysteine sulfenic acid(Cys51-SOH) when a peroxide is reduced. Because Cys51-SOH is unstable, it forms a disulfide with Cys172-SH which comes from the other subunit of the homodimer. The disulfide is then reduced back to the Prx active thiol form by the thioredoxin-thioredoxin reductase system. However, the formation of the disulfide is a slow process. Thus under oxidative stress conditions, the sulfenic intermediate(Cys51-SOH) can be easily over oxidized to cysteine sulfinic acid(Cys-SO2H) or cysteine sulfonic acid(Cys-SO3H) before it is able to form a disulfide. Recent studies suggest that over oxidized Prx can be reduced back to the active form during recovery after oxidative stress.

Function:
Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system. It is not able to receive electrons from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2).

Subunit:
Homodimer; disulfide-linked, upon oxidation. May be found as a toroid-shaped decamer composed of 5 dimers, depending on pH and calcium concentration. Interacts with TIPIN.

Peroxiredoxin 2,硫氧还蛋白过氧化物酶Ⅱ/巯基抗氧化蛋白抗体Subcellular Location:
Cytoplasm.

Similarity:
Belongs to the AhpC/TSA family.
Contains 1 thioredoxin domain.

Gene ID:
7001

Database links:
Entrez Gene: 286793 Cow
Entrez Gene: 7001 Human
Entrez Gene: 21672 Mouse
Entrez Gene: 29338 Rat
Omim: 600538 Human
SwissProt: Q9BGI3 Cow
SwissProt: P32119 Human
SwissProt: Q61171 Mouse
SwissProt: P35704 Rat
Unigene: 432121 Human
Unigene: 347009 Mouse
Unigene: 393373 Mouse
Unigene: 2511 Rat

Peroxiredoxin 2,硫氧还蛋白过氧化物酶Ⅱ/巯基抗氧化蛋白抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.