TRPM6,瞬时受体电位离子通道蛋白6抗体-抗体-抗体-生物在线
TRPM6,瞬时受体电位离子通道蛋白6抗体

TRPM6,瞬时受体电位离子通道蛋白6抗体

商家询价

产品名称: TRPM6,瞬时受体电位离子通道蛋白6抗体

英文名称: Anti-TRPM6 antibody

产品编号: HZ-9048R

产品价格: null

产品产地: 中国/美国

品牌商标: HZbscience

更新时间: 2023-08-17T10:24:20

使用范围: WB,ELISA,IHC-P,IHC-F,IF

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TRPM6,瞬时受体电位离子通道蛋白6抗体

产品编号HZ-9048R
英文名称TRPM6
中文名称瞬时受体电位离子通道蛋白6抗体(M亚家族)
别 名CHAK2; Channel kinase 2; HMGX; HOMG; HSH; Melastatin related TRP cation channel 6; Transient receptor potential cation channel subfamily M member 6; TRPM6_HUMAN.
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物 免疫学 信号转导 激酶和磷酸酶 通道蛋白
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Cow, Horse, Sheep,
TRPM6,瞬时受体电位离子通道蛋白6抗体产品应用ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:10-100 IF=1:50-200 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量232kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human TRPM6
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
TRPM6,瞬时受体电位离子通道蛋白6抗体PubMedPubMed
产品介绍background:
TRPM6 is an essential ion channel and serine/threonine-protein kinase, and is crucial for magnesium homeostasis. TRPM6 also has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. The various isoforms of the type M6-kinase lack the ion channel region.

Function:
Essential ion channel and serine/threonine-protein kinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Isoforms of the type M6-kinase lack the ion channel region.

Subunit:
Forms heterodimers with TRPM7. TRPM6 requires the presence of TRPM7 to be targeted to the cell membrane (in HEK 293 cells). Interacts (via kinase domain) with GNB2L1/RACK1.

Subcellular Location:
Membrane; Multi-pass membrane protein.

TRPM6,瞬时受体电位离子通道蛋白6抗体Tissue Specificity:
Highly expressed in kidney and colon. Isoform TRPM6a and isoform TRPM6b, are coexpressed with TRPM7 in kidney, and testis, and are also found in several cell lines of lung origin. Isoform TRPM6c is detected only in testis and in H510 small cell lung carcinoma cells.

DISEASE:
Defects in TRPM6 are the cause of hypomagnesemia type 1 (HOMG1) [MIM:602014]; also known as hypomagnesemia with secondary hypocalcemia (HSH). HOMG1 is a disorder due to a primary defect in intestinal magnesium absorption. It is characterized by low levels of serum magnesium alongside with a normal renal magnesium secretion, secondary hypocalcemia and calcinocis. Affected individuals show neurologic symptoms of hypomagnesemic hypocalcemia, including seizures and muscle spasms, during infancy. Hypocalcemia is secondary to parathyroid failure resulting from magnesium deficiency. Untreated, the disorder may be fatal or may result in neurological damage.

Similarity:
In the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.
In the N-terminal section; belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM6 sub-subfamily.
Database links:
Entrez Gene: 140803 Human
Omim: 607009 Human
SwissProt: Q5VYG5 Human
SwissProt: Q96LV9 Human
SwissProt: Q9BX84 Human

TRPM6,瞬时受体电位离子通道蛋白6抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.