HSPB2,热休克蛋白B2抗体

产品编号HZ-4782R
英文名称HSPB2
中文名称热休克蛋白B2抗体
别 名DMPK-binding protein; Heat shock 27kD protein 2; Heat shock 27kDa protein 2; Heat shock protein beta-2; Heat-shock protein beta-2; Hs.78846; HSP27; HspB2; HSPB2_HUMAN; LOH11CR1K; MGC133245; MKBP.
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物 免疫学 信号转导
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
HSPB2,热休克蛋白B2抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量20kDa
细胞定位细胞核 细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from hu HSPB2
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
HSPB2,热休克蛋白B2抗体PubMedPubMed
产品介绍background:
The heat shock proteins (HSPs) comprise a group of highly conserved, abundantly expressed proteins with diverse functions, including the assembly and sequestering of multi-protein complexes, transportation of nascent polypeptide chains across cellular membranes and regulation of protein folding. HSPB2 (heat shock 27 kDa protein 2), also known as HSP 27 or MKBP, is a 182 amino acid protein that belongs to the heat shock protein family and is expressed preferentially in heart and skeletal muscle. Localized to mitochondria, HSPB2 functions as an ATP-dependent chaperone protein that plays a role in the refolding of denatured proteins and may also interact with the Actin cytoskeleton and prevent apoptotic cell death. HSPB2 is abundantly expressed in several cancer cell lines, suggesting that HSPB2 may be an important factor in tumor transformation and metastasis.

Function:
May regulate the kinase DMPK.

Subunit:
Interacts with DMPK; may enhance its kinase activity.

Subcellular Location:
Cytoplasm. Nucleus. Localizes to nuclear foci.

Tissue Specificity:
Expressed preferentially in skeletal muscle and heart.

HSPB2,热休克蛋白B2抗体Similarity:
Belongs to the small heat shock protein (HSP20) family.

Database links:
Entrez Gene: 508671 Cow
Entrez Gene: 611362 Dog
Entrez Gene: 100736126 Guinea pig
Entrez Gene: 101828097 Hamster
Entrez Gene: 3316 Human
Entrez Gene: 69253 Mouse
Entrez Gene: 100520143 Pig
Entrez Gene: 161476 Rat
Omim: 602179 Human
SwissProt: Q16082 Human
SwissProt: Q99PR8 Mouse
SwissProt: O35878 Rat
Unigene: 709660 Human
Unigene: 1980 Mouse
Unigene: 22486 Rat

HSPB2,热休克蛋白B2抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.