Orai2,跨膜蛋白Orai2抗体

产品编号HZ-9541R
英文名称Orai2
中文名称跨膜蛋白Orai2抗体
别 名C7orf19; CAP binding protein complex interacting protein 2; CBCIP 2; CBCIP2; Chromosome 7 open reading frame 19; FLJ12474; FLJ14733; FLJ44818; H_NH0514P08.8; Orai 2; ORAI calcium release activated calcium modulator 2; Protein orai 2; TMEM 142B; TMEM142B; Transmembrane protein 142B.
说 明 书0.1ml 0.2ml
研究领域细胞生物 免疫学 通道蛋白
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, Sheep,
Orai2,跨膜蛋白Orai2抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量29kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Orai2
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Orai2,跨膜蛋白Orai2抗体PubMedPubMed
产品介绍background:
Orai2 is a 254 amino acid multi-pass membrane protein that belongs to the orai family of proteins. Localizing to the plasma membrane, Orai2 plays an important role in store-operated calcium (SOC) entry, a process involving Ca2+ influx and replenishment of Ca2+ stores formerly emptied through the action of inositol 1,4,5-trisphosphate production and other Ca2+ mobilizing agents. CRAC channels are responsible for medi-ating calcium influx in T-cells and play an important role in the immune response. Orai2 specifically increases the Ca2+-selective current through coaction with the Ca2+ sensor Stim1.

Function:
Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and increase in Ca(2+)-selective current by synergy with the Ca(2+) sensor, STIM1.

Subunit:
Interacts with EFCAB4B/CRACR2A.

Subcellular Location:
Membrane; Multi-pass membrane protein.

Similarity:
Belongs to the Orai family.

Database links:
Entrez Gene: 80228 Human
Entrez Gene: 269717 Mouse
Entrez Gene: 304592 Rat
Omim: 610929 Human
SwissProt: Q96SN7 Human
SwissProt: Q8BH10 Mouse
Unigene: 363308 Human
Unigene: 308396 Mouse
Unigene: 18207 Rat

Orai2,跨膜蛋白Orai2抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.