RIMBP2,神经元突触膜结合蛋白2抗体

产品编号HZ-11358R
英文名称RIMBP2
中文名称神经元突触膜结合蛋白2抗体
别 名RIM-BP2; RIMB2_HUMAN; RIMBP2; RIMS-binding protein 2.
说 明 书0.1ml 0.2ml
研究领域细胞生物 神经生物学 细胞类型标志物 细胞膜蛋白
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Horse,
RIMBP2,神经元突触膜结合蛋白2抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量116kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human RIMBP2
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
RIMBP2,神经元突触膜结合蛋白2抗体PubMedPubMed
产品介绍background:
RIMS-binding proteins (RIM-BPs) serve as adaptors during vesicle fusion and release by forming links between synaptic-vesicle fusion apparatuses and calcium channels. Specifically, RIM-BP2 (RIMS binding protein 2), also known as RBP2, is a 1,052 amino acid protein that links L-type Ca++ CP Alpha1D, N-type Ca++ CP Alpha1B, Rim1 and Rim2 during synaptic transmission. RIM-BP2 contains three fibronectin type-III domains and three SH3 domains, which are used to mediate binding to a proline-rich motifs. Existing as three alternatively spliced isoforms, RIM-BP2 is encoded by a gene that maps to human chromosome 12q24.33 and mouse chromosome 5 G1.3.

Function:
Plays a role in the synaptic transmission as bifunctional linker that interacts simultaneously with RIMS1, RIMS2, CACNA1D and CACNA1B.

Subunit:
Interacts with RIMS1, RIMS2, CACNA1D and CACNA1B, and potentially with other Ca(2+) channel alpha-1 isoforms (By similarity).

RIMBP2,神经元突触膜结合蛋白2抗体Subcellular Location:
Cell membrane (By similarity). Cell junction, synapse (By similarity). Note=Synaptic plasma membrane (By similarity).

Tissue Specificity:

Similarity:
Belongs to the RIMBP family.
Contains 3 fibronectin type-III domains.
Contains 3 SH3 domains.

Database links:
UniProtKB/Swiss-Prot: O15034.3

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.