Anti-RheB Mouse Monoclonal Antibody-抗体-抗体-生物在线
武汉纽斯特生物技术有限公司
Anti-RheB Mouse Monoclonal Antibody

Anti-RheB Mouse Monoclonal Antibody

商家询价

产品名称： Anti-RheB Mouse Monoclonal Antibody

英文名称： Anti-RheB Mouse Monoclonal Antibody

产品编号： 26015

产品价格： null

产品产地： 美国

品牌商标： NewEastbio

更新时间： null

使用范围： ELISA, WB, IHC

武汉纽斯特生物技术有限公司
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RheB [26015]
[100 µL]		  

Catalog Number:  26015
Gene Symbol:  RHEB
Description:   Anti-RheB Mouse Monoclonal Antibody
Background:   RheB (Ras Homolog Enriched in Brain) is an evolutionarily conserved member of the Ras-family of small GTP-binding proteins originally found to be rapidly induced by synaptic activity in the hippocampus following seizure. While it is expressed at relatively high levels in the brain, RheB is widely expressed in other tissues and may be induced by growth factor stimulation. RheB has an important role in regulating the insulin/TOR signaling pathway. The mammalian target of rapamycin, mTOR, is a serine/threonine protein kinase that acts as a sensor for ATP and amino acids, balancing the availability of nutrients with translation and cell growth. The tuberin/hamartin (TSC2/TSC1) complex inhibits mTOR activity indirectly by inhibiting RheB via tuberin's GAP activity.
Immunogen:   Recombinant full length protein of RheB.
Applications:   ELISA, WB, IHC
Recommended Dilutions:   
ELISA: 1:100-1:5000
WB: 1:100-1:2000
IHC: 1:50-1:100
Concentration:   1 mg/ml
Host:   mouse
Format:   Liquid
Clonality:   Monoclonal
Isotype:   IgG
Purity:   Purified from ascites
Storage buffer:
Preservative:  no
Constituents:  PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol
Species Reactivity:  RheB antibody recognizes RheB proteins of vertebrates.
 
Western blot:  
Western blot analysis of RheB proteins. HEK-293 whole-cell lysate was used for Western blot.
 

 

Publications:
1.  Inducible Nitric Oxide Synthase Drives mTOR Pathway Activation and Proliferation of Human Melanoma by Reversible Nitrosylation of TSC2
    Cancer Res. 2014 Feb 15;74(4):1067-78
2.  SynGAP Regulates Protein Synthesis and Homeostatic Synaptic Plasticity in Developing Cortical Networks
    PLoS One. 2013 Dec 31;8(12):e83941