FITC标记的TSK蛋白抗体
产品名称: FITC标记的TSK蛋白抗体
英文名称: Anti-Tsukushin/FITC
产品编号: HZ-11607R-FITC
产品价格: null
产品产地: 中国/上海
品牌商标: HZbscience
更新时间: 2023-08-17T10:24:20
使用范围: ICC=1:50-200 IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
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- 邮箱 : www.shzbio.net
Rabbit Anti-Tsukushin/FITC Conjugated antibody
FITC标记的TSK蛋白抗体
产品编号 | bs-11607R-FITC |
英文名称 | Anti-Tsukushin/FITC |
中文名称 | FITC标记的TSK蛋白抗体 |
别 名 | E2 induced gene 4 protein; E2IG4; Leucine rich repeat containing protein 54; LRRC54; TSK; Tsukushi; TSK_HUMAN; Tsukushin. |
规格价格 | 100ul/2980元 购买 大包装/询价 |
说 明 书 | 100ul |
研究领域 | 细胞生物 神经生物学 信号转导 干细胞 生长因子和激素 转录调节因子 |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, |
产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 36kDa |
性 状 | Lyophilized or Liquid |
浓 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human Tsukushin |
亚 型 | IgG |
纯化方法 | affinity purified by Protein A |
储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
产品介绍 | background: The leucine-rich (LRR) repeat is a 20-30 amino acid motif that forms a hydrophobic å/∫ horseshoe fold, allowing it to accommodate several leucine residues within a tightly packed core. All LRR repeats contain a variable segment and a highly conserved segment, the latter of which accounts for 11 or 12 residues of the entire LRR motif. LRRC54 (leucine-rich repeat-containing protein 54), also known as tsukushin, TSKU or E2-induced gene 4 protein (E2IG4), is a 353 amino acid secreted protein that likely localizes to the cell membrane and extracellular compartments. Involved in extracellular secretion and intracellular transport, LRRC54 can be induced by 17-beta-estradiol. Containing nine LRR repeat and a cleavable signal peptide, the gene encoding LRRC54 maps to human chromosome 11, which houses over 1,400 genes and comprises nearly 4% of the human genome. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are associated with defects in genes that maps to chromosome 11. Function: It is suggested that Tsukushin is involved in intracellular transport and extracellular secretion. Its structure contains 9 LRR (leucine-rich) repeats. Subcellular Location: Secreted Similarity: Contains 10 LRR (leucine-rich) repeats. Contains 1 LRRNT domain. Database links: Entrez Gene: 25987 Human GenBank: NM_015516 Human GenBank: NP_056331 Human Omim: 608015 Human SwissProt: Q8WUA8 Human Unigene: 8361 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
富含亮氨酸(LRR)的重复序列是20-30个氨基酸基序,形成疏水性/马蹄形褶皱,允许其在紧密堆积的核心内容纳多个亮氨酸残基。所有的LRR重复包含可变片段和高度保守的片段,后者占整个LRR基序的11或12个残基。LRRC54(富含亮氨酸重复序列的含蛋白质54),也称为Tukkuin,TSKU或E2诱导的基因4蛋白(E2IG4),是一种353氨基酸分泌蛋白,可能定位于细胞膜和细胞外室。17β-雌二醇可诱导LRRC54在细胞外分泌和胞内转运。含有九个LRR重复序列和一个可裂解信号肽,编码LRRC54的基因映射到人类11号染色体,其含有超过1400个基因,并且包含人类基因组的近4%。Jevl和Lange Nielsen综合征、杰克布森综合征、尼曼匹克病、遗传性血管水肿和Smith-LeMi-Opz综合征与11号染色体上的基因缺陷有关。