FITC标记的跨膜蛋白SEMA5A抗体
产品名称: FITC标记的跨膜蛋白SEMA5A抗体
英文名称: Anti-Semaphorin 5A/FITC
产品编号: HZ-11481R-FITC
产品价格: null
产品产地: 中国/上海
品牌商标: HZbscience
更新时间: 2023-08-17T10:24:20
使用范围: ICC=1:50-200 IF=1:50-200
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Rabbit Anti-Semaphorin 5A/FITC Conjugated antibody
FITC标记的跨膜蛋白SEMA5A抗体
产品编号 | bs-11481R-FITC |
英文名称 | Anti-Semaphorin 5A/FITC |
中文名称 | FITC标记的跨膜蛋白SEMA5A抗体 |
别 名 | Semaphorin 5A; Semaphorin-5A; Semaphorin5A; SEMA5A; SEMAF; Semaphorin F; SEM5A_HUMAN. |
规格价格 | 100ul/2980元 购买 大包装/询价 |
说 明 书 | 100ul |
研究领域 | 细胞生物 神经生物学 细胞膜蛋白 |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, |
产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 118kDa |
细胞定位 | 细胞膜 |
性 状 | Lyophilized or Liquid |
浓 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human SEMA5A/Semaphorin 5A |
亚 型 | IgG |
纯化方法 | affinity purified by Protein A |
储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
产品介绍 | background: This gene belongs to the semaphorin gene family that encodes membrane proteins containing a semaphorin domain and several thrombospondin type-1 repeats. Members of this family are involved in axonal guidance during neural development. This gene has been implicated as an autism susceptibility gene. Function: Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs) (By similarity). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. May promote angiogenesis by increasing endothelial cell proliferation and migration and inhibiting apoptosis. Subunit: Binds PLXNB3. Subcellular Location: Membrane; single-pass type I membrane protein Similarity: Belongs to the semaphorin family. Contains 1 PSI domain. Contains 1 Sema domain. Contains 7 TSP type-1 domains. Database links: Entrez Gene: 9037 Human Entrez Gene: 20356 Mouse Omim: 609297 Human SwissProt: Q13591 Human SwissProt: Q62217 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
该基因属于SimaPrChin基因家族,编码含有信号素域和几种血小板反应蛋白-1型重复序列的膜蛋白。该家族成员参与神经发育过程中的轴突导向。这一基因被认为是自闭症易感基因。