FITC标记的细胞膜钙ATP酶1抗体
产品名称： FITC标记的细胞膜钙ATP酶1抗体
英文名称： Anti-PMCA1/FITC
产品编号： HZ-4978R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749
- 传真 : 021-60345367
- 邮箱 : www.shzbio.net
Rabbit Anti-PMCA1/FITC Conjugated antibody
FITC标记的细胞膜钙ATP酶1抗体
| 英文名称 | Anti-PMCA1/FITC |
| 中文名称 | FITC标记的细胞膜钙ATP酶1抗体 |
| 别 名 | AT2B1_HUMAN; ATP2B1; ATPase Ca++ transporting plasma membrane 1; Plasma membrane calcium ATPase 1; Plasma membrane calcium ATPase isoform 1; Plasma membrane calcium pump isoform 1; Plasma membrane calcium transporting ATPase 1; Plasma membrane calcium-transporting ATPase 1; PMCA 1; PMCA1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 免疫学 神经生物学 信号转导 转录调节因子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 138kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PMCA1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Plasma membrane-type Ca2+-ATPases (PMCAs) mediate the export of bivalent calcium ions from eukaryotic cells. As members of the P class of ion-motive ATPases, PMCAs are a functionally diverse group of proteins that are derived from alternatively spliced transcripts originating from at least four distinct genes. The expression of different PMCA isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, and with respect to the physiological needs of specific cell and tissue types. Spatial and temporal rates of resting intracellular Ca2+ concentrations and Ca2+ signaling in eukaryotic cells are dependent on the array of PMCA isoforms that are expressed in concert with the rate of Ca2+ export. PMCA1 (ATP2B1) is a ubiquitously expressed form of the PMCA calcium exporter family. Function: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Isoform B is ubiquitously expressed. Isoform C is found in brain cortex, skeletal muscle and heart muscle. Isoform D has only been found in fetal skeletal muscle. Isoform K has been found in small intestine and liver. Similarity: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily. Database links: Entrez Gene: 490 Human Entrez Gene: 67972 Mouse Entrez Gene: 397636 Pig Entrez Gene: 29598 Rat Omim: 108731 Human SwissProt: P20020 Human SwissProt: P23220 Pig SwissProt: P11505 Rat Unigene: 506276 Human Unigene: 7208 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
质膜型Ca2+ - ATPases（PCAMAs）介导了真核细胞中的二价钙离子的输出。作为P类离子动力ATPases的成员，PMCA是一组功能多样的蛋白质，它们来源于来源于至少四个不同基因的选择性剪接的转录本。不同PMCA亚型和剪接变异体的表达以发育、组织和细胞类型特异性的方式调节，并根据特定细胞和组织类型的生理需要调节。真核细胞中静止胞内Ca2+浓度和Ca2+信号传导的时空速率取决于与Ca2+输出速率一致表达的PMCA亚型阵列。PMCA1（ATP2 B1）是PMCA钙出口家族的一种普遍表达的形式。