FITC标记的补体因子D抗体
产品名称： FITC标记的补体因子D抗体
英文名称： Anti-Factor D/FITC
产品编号： HZ-13130R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-Factor D/FITC Conjugated antibody
FITC标记的补体因子D抗体
| 英文名称 | Anti-Factor D/FITC |
| 中文名称 | FITC标记的补体因子D抗体 |
| 别 名 | adipsin; Adipsin/complement factor D; adn; C3 convertase activator; CFAD_HUMAN; CFD; Complement factor D; complement factor D preproprotein; D component of complement; DF; FactorD; PFD; Properdin factor D. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 24kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Factor D/Adipsin |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Adipsin is the mouse homolog of the previously described human complement Factor D, a serine protease, which is now designated human Adipsin. Human Adipsin is highly expressed in and secreted by adipose tissue, and it has also been found in monocytes and macrophages. Rodent Adipsin has only been detected in high levels in adipose tissue. It has been shown that complement factor B, when complexed with activated complement component C3, is cleaved by Adipsin. While low expression of Adipsin has been confirmed in obese mice with hypothalamic defects, this inverse correlation between Adipsin expression and obesity has not been demonstrated in humans. Function: Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway. Subcellular Location: Secreted. DISEASE: Defects in CFD are the cause of complement factor D deficiency (CFD deficiency) [MIM:134350]. CFD deficiency predisposes to invasive meningococcal disease. Similarity: Belongs to the peptidase S1 family. Contains 1 peptidase S1 domain. Database links: Entrez Gene: 1675 Human Omim: 134350 Human SwissProt: P00746 Human Unigene: 155597 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application |
脂蛋白是先前描述的人补体因子D（一种丝氨酸蛋白酶）的小鼠同源物，现在称为人脂蛋白。人Adipsin在脂肪组织中有高表达和分泌，在单核细胞和巨噬细胞中也有发现。仅在脂肪组织中高水平检测到啮齿动物的己二酸。已经证明，补体因子B与活化补体成分C3络合时，被Adipsin裂解。虽然在下丘脑缺损的肥胖小鼠中证实了脂联素的低表达，但是在人类中没有证实脂联素表达与肥胖之间的这种反相关。