FITC标记的肝细胞核因子1β/HNF-1β抗体
产品名称： FITC标记的肝细胞核因子1β/HNF-1β抗体
英文名称： Anti-HNF1 beta/FITC
产品编号： HZ-8617R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-HNF1 beta/FITC Conjugated antibody
FITC标记的肝细胞核因子1β/HNF-1β抗体
| 英文名称 | Anti-HNF1 beta/FITC |
| 中文名称 | FITC标记的肝细胞核因子1β/HNF-1β抗体 |
| 别 名 | FJHN; Hepatocyte nuclear factor 1 beta; Hepatocyte nuclear factor 1-beta; HNF 1B; HNF 2; HNF-1-beta; HNF-1B; HNF1B; HNF1 beta; HNF1 homeobox B; HNF1B; HNF1B_HUMAN; HNF1beta; HNF2; Homeoprotein LF B3; Homeoprotein LFB3; HPC11; LF B3; LFB3; MODY 5; MODY5; TCF 2; TCF 2 protein; TCF-2; TCF2; TCF2 protein; Transcription factor 2; Transcription factor 2 hepatic; Variant hepatic nuclear factor 1; Variant hepatic nuclear factor; VHNF 1; vHNF1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 染色质和核信号 新陈代谢 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Zebrafish, Sheep, Xenopus laevis |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 61kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human HNF1 beta |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: HNF-1 (a and b), HNF-3 (a, b and g), HNF-4 (a and g) and HNF-6 compose, in part, a homoeprotein family designated the hepatocyte nuclear factor family. The various HNF-1 isoforms regulate transcription of genes in the liver as well as in other tissues such as kidney, small intestine and thymus. HNF-3a, HNF-3b and HNF-3g regulate the transcription of numerous hepatocyte genes in adult liver. HNF-3a and HNF-3b have also been shown to be involved in gastrulation events such as body axis formation. HNF-4a and HNF-4g have been shown to be important for early embryo development. HNF-4a is expressed in liver, kidney, pancreas, small intestine, testis and colon; and HNF-4g is expressed in each of these tissues except liver. HNF-6 has been shown to bind to the promoter of HNF-3b, which indicates a potential role of HNF-6 in gut endoderm epithelial cell differentiation. Evidence suggests that HNF-6 may also be a transriptional activator for at least 22 other hepatocyte-enriched genes, including cytochrome P450 2C13 and a-1 antitrypsin. Function: Transcription factor, probably binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Subcellular Location: Nucleus. DISEASE: Defects in HNF1B are the cause of renal cysts and diabetes syndrome (RCAD) [MIM:137920]; also called maturity-onset diabetes of the young type 5 (MODY5) or familial hypoplastic glomerulocystic kidney disease (GCKD). RCAD is an autosomal dominant disorder comprising non-diabetic renal disease resulting from abnormal renal development, and diabetes, which in some cases occurs earlier than age 25 years and is thus consistent with a diagnosis of maturity-onset diabetes of the young (MODY5). The renal disease is highly variable and includes renal cysts, glomerular tufts, aberrant nephrogenesis, primitive tubules, irregular collecting systems, oligomeganephronia, enlarged renal pelves, abnormal calyces, small kidney, single kidney, horseshoe kidney, and hyperuricemic nephropathy. Defects in HNF1B may be rare genetic risk factor contributing to the development of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:125853]. NIDDM is characterized by an autosomal dominant mode of inheritance, onset during adulthood and insulin resistance. Defects in HNF1B may be a cause of susceptibility to prostate cancer hereditary type 11 (HPC11) [MIM:611955]. It is a condition associated with familial predisposition to cancer of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. Similarity: Belongs to the HNF1 homeobox family. Contains 1 homeobox DNA-binding domain. Database links: Entrez Gene: 6928 Human Entrez Gene: 21410 Mouse Entrez Gene: 397002 Pig Entrez Gene: 25640 Rat Entrez Gene: 140745 Zebrafish Omim: 189907 Human SwissProt: P35680 Human SwissProt: P27889 Mouse SwissProt: Q03365 Pig SwissProt: P23899 Rat SwissProt: Q91910 Xenopus laevis SwissProt: A1L1N5 Zebrafish Unigene: 191144 Human Unigene: 7226 Mouse Unigene: 11342 Rat Unigene: 12667 Xenopus laevis Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
HNF-1（HNF-3和（b），（a，b和g（HNF），4 -和6 - G）和肼组成，特别是在家庭，homoeprotein核因子家族的主要茶叶理想的肝细胞来源。不同贮藏isoforms the HNF-1基因转录在肝脏as of the other such as as在阱的内部小组织，肾和胸腺。HNF—3A，3B和3G的肼肼of the贮藏理想的肝细胞来源numerous基因转录在成人肝。HNF—3A和3B have also been shown HNF—to be involved such as在原肠胚形成和体轴。肼和肼- 4A的4G have been shown to be important for早期胚胎发展。HNF—4A是表达在肝，肾，胰腺，结肠和小睾丸；和内部的HNF 4G is expressed in each of these除肝组织。HNF has been shown to bind - 6启动子- 3B的HNF to the of which of indicates潜在的角色，在肠道内胚层epithelial HNF4 - 6细胞分化。suggests HNF 6证据，也可能成为transriptional激活剂least for other 22理想的肝细胞来源的细胞色素P450基因型，包括2c13 - 1和抗胰蛋白酶。