FITC标记的MS4A15蛋白抗体
产品名称： FITC标记的MS4A15蛋白抗体
英文名称： Anti-MS4A15/FITC
产品编号： HZ-13691R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-MS4A15/FITC Conjugated antibody
FITC标记的MS4A15蛋白抗体
| 英文名称 | Anti-MS4A15/FITC |
| 中文名称 | FITC标记的MS4A15蛋白抗体 |
| 别 名 | FLJ34527; Hypothetical protein MGC35295; M4A15_HUMAN; Membrane spanning 4 domains subfamily A member 15; Membrane-spanning 4-domains subfamily A member 15; MGC35295; MS4A15. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 跨膜蛋白 细胞膜蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 25kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MS4A15 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: MS4A (membrane-spanning 4-domain family, subfamily A) is a large family of proteins that includes at least 26 members in mouse and humans. Flanked by amino- and carboxyl- cytoplasmic regions, MS4A family members contain four highly conserved transmembrane domains. CD20, the most well-known MS4A family member, is a B-cell-specific molecule that functions as a calcium-permeable cation channel and is known to accelerate the G0 to G1 progression induced by IGF-1. MS4A15 (membrane-spanning 4-domains, subfamily A, member 15) is a 240 amino acid multi-pass membrane protein that exists as two alternatively spliced isoforms. The gene encoding MS4A15 maps to human chromosome 11, which houses over 1,400 genes and comprises nearly 4% of the human genome. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are associated with defects in genes that maps to chromosome 11. Function: May be involved in signal transduction as a component of a multimeric receptor complex. Subcellular Location: Membrane. Similarity: Belongs to the MS4A family. Database links: Entrez Gene: 219995 Human Entrez Gene: 545279 Mouse SwissProt: Q8N5U1 Human SwissProt: Q3UPL6 Mouse Unigene: 207465 Human Unigene: 329729 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
MS4A（跨膜4结构域家族，A亚家族）是蛋白质的大家族，在小鼠和人类中至少包括26个成员。Ms4A家族成员由氨基酸和羧基细胞质区域组成，共含有四个高度保守的跨膜结构域。CD20是最著名的MS4A家族成员，是一种B细胞特异性分子，其作用是钙渗透性阳离子通道，并已知可加速IGF-1诱导的G0至G1的进展。MS4A15（跨膜4结构域，亚家族A，成员15）是一种240个氨基酸的多路膜蛋白，以两种可选择的剪接异构体存在。编码MS4A15的基因映射到人类第11号染色体，该基因含有1400个以上的基因，并包含人类基因组的近4%。Jervell和Lange-Nielsen综合征、Jac.n综合征、Niemann-Pick病、遗传性血管水肿和Smith-Lemli-Opitz综合征与映射到11号染色体的基因缺陷有关。