FITC标记的轴丝动力蛋白12抗体
产品名称： FITC标记的轴丝动力蛋白12抗体
英文名称： Anti-DNAH12/FITC
产品编号： HZ-14361R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
上海沪震实业有限公司
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Rabbit Anti-DNAH12/FITC Conjugated antibody
FITC标记的轴丝动力蛋白12抗体
| 英文名称 | Anti-DNAH12/FITC |
| 中文名称 | FITC标记的轴丝动力蛋白12抗体 |
| 别 名 | DYH12_HUMAN; Dynein heavy chain 12, axonemal; Axonemal beta dynein heavy chain 12; Axonemal dynein heavy chain 12-like protein; Axonemal dynein heavy chain 12 like protein; Axonemal dynein heavy chain 7-like protein; Ciliary dynein heavy 12; Dynein heavy chain 7-like, axonemal; Axonemal dynein heavy chain 7 like protein; Dynein heavy chain domain-containing protein 2; DHC3; DLP12; DNAH12L; DNAH7L; DNAHC3; DNHD2; HDHC3; HL19. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 细胞骨架 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 357kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DNAH12 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Dyneins are multisubunit, high molecular weight ATPases that interact with microtubules to generate force by converting the chemical energy of ATP into the mechanical energy of movement. Cytoplasmic or axonemal dynein heavy, intermediate, light and light-intermediate chains are all components of minus end-directed motors; complexes that transport cellular cargo toward the central region of the cell. Axonemal dynein motors contain one to three non-identical heavy chains and cause a sliding of microtubules in the axonemes of cilia and flagella in a mechanism necessary for cilia to beat and propel the cell. DNAH12 is a 3,092 amino acid protein of cilium axoneme that exists as three alternatively spliced isoforms. A member of the dynein heavy chain family, DNAH12L is involved in sperm flagellar assembly and is encoded by a gene located on human chromosome 3. Function: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly Subunit: Consists of at least two heavy chains and a number of intermediate and light chains. Subcellular Location: Cytoplasm, cytoskeleton, cilium axoneme. Similarity: Belongs to the dynein heavy chain family. Database links: Entrez Gene: 201625 Human SwissProt: Q6ZR08 Human Unigene: 201378 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
动力蛋白是多亚基、高分子量的ATPase，它与微管相互作用，通过将ATP的化学能转化为运动的机械能来产生力。细胞质或轴丝状动力蛋白重链、中间链、轻链和轻中间链都是负端向马达的组成部分；复合体将细胞货物运输到细胞的中心区域。轴丝动力蛋白马达包含一至三个不相同的重链，在纤毛和鞭毛的轴丝中导致微管滑动，这是纤毛搏动和推动细胞所必需的机制。DNaH12是纤毛轴突的3092个氨基酸蛋白，以三个交替剪接的亚型存在。DNAH12L是强力蛋白重链家族的成员，参与精子鞭毛装配，由位于人类3号染色体上的基因编码。