FITC标记的DNAJC5B蛋白抗体
产品名称： FITC标记的DNAJC5B蛋白抗体
英文名称： Anti-DNAJC5B/FITC
产品编号： HZ-14393R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
上海沪震实业有限公司
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Rabbit Anti-DNAJC5B/FITC Conjugated antibody
FITC标记的DNAJC5B蛋白抗体
| 英文名称 | Anti-DNAJC5B/FITC |
| 中文名称 | FITC标记的DNAJC5B蛋白抗体 |
| 别 名 | Beta CSP; Beta cysteine string protein; CSP beta; DNJ5B_HUMAN; DnaJ (Hsp40) homolog, subfamily C, member 5 beta; DnaJ homolog subfamily C member 5B; MGC26226. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 转运蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 22kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DNAJC5B |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The DnaJ family, one of the largest of all the chaperone families, has evolved with diverse cellular localization and functions. The presence of the J domain defines a protein as a member of the DnaJ family. DnaJ heat-shock induced proteins are derived from the bacterium Escherichia coli and are under the control of the htpR regulatory protein. The DnaJ proteins play a critical role in the HSP 70 chaperone machine by interacting with HSP 70 to stimulate ATP hydrolysis. Members of this family contain cysteine-rich regions that are composed of zinc fingers that form a peptide-binding domain responsible for the chaperone function. They are important mediators of proteolysis and are involved in the regulation of protein degradation, exocytosis and endocytosis. DnaJC5B is a 199 amino acid protein that contains one J domain and plays an important role in exocytosis. DnaJC5B is expressed in testis where it is tightly bound to lipid membranes. The palmitoylation level of DnaJC5B is thought to correlate with its targeting to specific membranes. Function: DnaJ is a testis-specific heat shock protein and functions in association with DnaK(Hsp70). It is a molecular chaperone to facilitate protein folding. DnaJ plays a key role in the chaperone reaction by stimulating the ATPase activity and activating the substrate binding of Hsp70. Subcellular Location: Membrane; Lipid-anchor. Tissue Specificity: Testis specific. Post-translational modifications: Palmitoylated. Palmitoylation is not required for membrane association. Similarity: Contains 1 J domain. Database links: Entrez Gene: 85479 Human Entrez Gene: 66326 Mouse GenBank: NM_033105 Human SwissProt: Q9UF47 Human SwissProt: Q9CQ94 Mouse Unigene: 491885 Human Unigene: 45615 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
DnaJ家族是所有伴侣分子家族中最大的家族之一，其进化具有不同的细胞定位和功能。J域的存在定义了作为DnaJ家族成员的蛋白质。DNJ热休克诱导蛋白来源于细菌大肠杆菌，并在HTPR调节蛋白的控制下。DHNJ蛋白通过与HSP 70相互作用，在HSP 70伴侣机器中起关键作用，以刺激ATP水解。这个家族的成员含有富含半胱氨酸的区域，这些区域由锌指组成，锌指形成负责伴侣功能的肽结合结构域。它们是蛋白质水解的重要介质，参与蛋白质降解、胞吐和内吞的调节。DNaJC5B是一个含有199个J结构域的蛋白质，在胞吐作用中起着重要作用。DNJC5B在睾丸中表达，与脂质膜紧密结合。DNaJC5B的棕榈酰化水平被认为是CORR。