FITC标记的HA1蛋白抗体
产品名称: FITC标记的HA1蛋白抗体
英文名称: Anti-HA1/FITC
产品编号: HZ-16380R-FITC
产品价格: null
产品产地: 中国/上海
品牌商标: HZbscience
更新时间: 2023-08-17T10:24:20
使用范围: ICC=1:50-200 IF=1:50-200
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Rabbit Anti-HA1/FITC Conjugated antibody
FITC标记的HA1蛋白抗体
英文名称 | Anti-HA1/FITC |
中文名称 | FITC标记的HA1蛋白抗体 |
别 名 | HLA HA1; HMHA1_HUMAN; HMHA1; KIAA0223; mHag HA-1; Minor histocompatibility antigen HA 1; Minor histocompatibility protein HA 1. |
规格价格 | 100ul/2980元 购买 大包装/询价 |
说 明 书 | 100ul |
研究领域 | 免疫学 转运蛋白 淋巴细胞 t-淋巴细胞 |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Sheep, |
产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 125kDa |
性 状 | Lyophilized or Liquid |
浓 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human HA1 |
亚 型 | IgG |
纯化方法 | affinity purified by Protein A |
储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
产品介绍 | background: Major histocompatibility complex (MHC) molecules, which include human leukocyte antigens (HLAs), form an integral part of the immune response system. They are cell-surface receptors that bind foreign peptides and present them to cytotoxic T lymphocytes (CTLs). Minor histocompatibility antigens can form an immune response upon recognition by certain T-cells when complexed with MHC molecules. HA-1 (minor histocompatibility protein HA-1), also known as HA-1, HLA-HA1 or HMHA1, is a 1,136 amino acid GTPase activator of Rho-type GTPases. Expressed in dendritic cells, epidermal Langerhans cells, hematopoietic cells, peripheral blood mononuclear cells and all leukemia and lymphoma cell lines, HA-1 is also found in various solid tissues and tumors. Highly phosphorylated, HA-1 contains one Rho-GAP domain, a single phorbol-ester/DAG-type zinc finger and is encoded by a gene located on human chromosome 19p13.3. Function: The minor histocompatibility antigen (mHags), HA-1 is a immunogenic alloantigen shown to be responsible for graft-versus-host disease (GVHD) in HLA-identical bone marrow transplantation. The antigen has two known alleles resulting in a single amino acid polymorphism. The HA-1H allele encodes histidine, whereas the HA-1R allele encodes arginine. Subunit: HA-1 forms a complex with MHC class I HLA-A*0201. Subcellular Location: Cytoplasmic Tissue Specificity: Expressed on cells of the hematopoietic lineage. Detected in dendritic cells and epidermal Langerhans cells. Expressed in peripheral blood mononuclear cells, in all leukemia/lymphoma cell lines. Detected also in some solid tumors and tissues such as cancerous and non-cancerous tissue Similarity: Contains 1 phorbol-ester/DAG-type zinc finger. Contains 1 Rho-GAP domain. Database links: Entrez Gene: 23526 Human Entrez Gene: 70719 Mouse Entrez Gene: 314618 Rat Omim: 601155 Human SwissProt: Q92619 Human SwissProt: Q3TBD2 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
主要组织相容性复合物(MHC)分子,包括人类白细胞抗原(HLA),构成了免疫应答系统的组成部分。它们是结合外源肽的细胞表面受体,并呈递给细胞毒性T淋巴细胞(CTL)。次级组织相容性抗原与MHC分子复合后,经某些T细胞识别可形成免疫应答。HA-1(次级组织相容性蛋白HA-1),又称HA-1、HLA-HA1或HMHA1,是Rho型GTPase的1136个氨基酸GTPase激活剂。HA-1在树突状细胞、表皮郎格罕细胞、造血细胞、外周血单个核细胞以及所有白血病和淋巴瘤细胞系中均有表达,在各种实体组织和肿瘤中也有表达。HA-1高度磷酸化,包含一个Rho-GAP结构域,一个佛波酯/DAG型锌指并且由位于人类染色体19p13.3上的基因编码。