NTAL (6A454)上海美吉生物医药科技有限公司

性能参数

产品名称: NTAL (6A454)
英文名称: NTAL (6A454)
抗体货号: sc-71731
产品规格: 100 µg/ml
产品产地: 美国原装
品牌商标: santa cruz biotechno
价    格: 1750元
抗原: NTAL
抗原来源: •mouse mo
抗体来源: 
适用物种: LAT2 (human)
应用范围: 
更新时间: 2019/4/20 12:09:00
详细资料:  资料下载
浏览人数:4276
诚信指数:1506点
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使用范围:仅限科研使用,不能应用于临床
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生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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上海美吉生物医药科技有限公司
地址:
上海市浦东新区国际医学园区康新公路3399弄3号楼
邮编:
201203
电话:
021-51875086
传真:
021-51875086-8002
联系人:
所在区域:
上海·上海
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产品详细描述

现货1750促销

 

BACKGROUND
Non-T cell activation linker (NTAL), a transmembrane adaptor protein, is
also designated membrane-associated adapter molecule, Williams-Beuren
syndrome chromosome region 15 protein or LAB (linker of activated B cells).
NTAL is present in membrane microdomains (rafts) of B cells, NK cells and
myeloid cells, and in monocytes and mast cells, but not in resting T lymphocytes.
NTAL becomes rapidly tyrosine-phosphorylated upon cross-linking of
the B cell receptor (BCR) or of high-affinity Fc γ and Fc ε receptors of myeloid
cells and then associates with the cytoplasmic signaling molecules. NTAL is
highly expressed in spleen, lymph node germinal centers and peripheral blood
lymphocytes. Defects in the gene encoding for NTAL may cause the musculoskeletal
and cardiovascular abnormalities that characterize the rare developmental
disorder Williams-Beuren syndrome (WBS).

REFERENCES
1. Martindale, D.W., Wilson, M.D., Wang, D., Burke, R.D., Chen, X., Duronio,
V. and Koop, B.F. 2000. Comparative genomic sequence analysis of the
Williams syndrome region (LIMK1-RFC2) of human chromosome 7q11.23.
Mamm. Genome 11: 890-898.
2. Janssen, E., Zhu, M., Zhang, W., Koonpaew, S. and Zhang, W. 2003. LAB:
a new membrane-associated adaptor molecule in B cell activation. Nat.
Immunol. 4: 117-123.
3. Tkaczyk, C., Horejsi, V., Iwaki, S., Draber, P., Samelson, L.E., Satterthwaite,
A.B., Nahm, D.H., Metcalfe, D.D. and Gilfillan, A.M. 2004. NTAL phosphorylation
is a pivotal link between the signaling cascades leading to human
mast cell degranulation following Kit activation and Fc ε RI aggregation.
Blood 104: 207-214.
4. Koonpaew, S., Janssen, E., Zhu, M. and Zhang, W. 2004. The importance
of three membrane-distal tyrosines in the adaptor protein NTAL/LAB. J.
Biol. Chem. 279: 11229-11235.
5. Tedoldi, S., Paterson, J.C., Hansmann, M.L., Natkunam, Y., Rüdiger, T.,
Angelisova, P., Du, M.Q., Roberton, H., Roncador, G., Sanchez, L., Pozzobon,
M., Masir, N., Barry, R., Pileri, S., Mason, D.Y., Marafioti, T. and Horejsí, V.
2005. Transmembrane adaptor molecules: a new category of lymphoid-cell
markers. Blood 107: 213-221.

 

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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