Recombinant Rat Interleukin-9 (Rat IL-9)
产品名称： Recombinant Rat Interleukin-9 (Rat IL-9)
英文名称： Recombinant Rat Interleukin-9 (Rat IL-9)
产品编号： 90173ES10
产品价格： 0
产品产地： Yeasen
品牌商标： Yeasen
更新时间： 2023-08-17T13:40:59
使用范围： null
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- 邮编 : 200030
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- 传真 : 021-34615995-188
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Product Information
Product Name
Cat#
Size
Price（¥）
Recombinant Rat Interleukin-9 (Rat IL-9)
90173ES10
10 μg
1,855
90173ES60
100 μg
13,615
90173ES76
500 μg
35,395
Product Description
Interleukin-9 (IL-9), also known as P40 and MEA (mast cell growth-enhancing activity), is a 30-40 kDa glycosylated member of a cytokine family that includes Interleukins-2, -4, -7, -15, and -21. These proteins utilize heteromeric receptors containing the Common gamma chain ( gamma c) in addition to ligand-specific subunits. IL-9 interacts selectively with IL-9 R which then associates with gamma c to form the functional receptor complex. IL9 contributes to allergic inflammation, autoimmunity-induced inflammation, parasite clearance from the GI tract, and Treg-mediated immune suppression. It enhances the expansion and recruitment of mast cells and eosinophils as well as the production of IgE and Th2 cytokines. It is required for anaphylactic responses to ingested allergens but not to systemic allergens. IL-9 plays multiple roles in the development and function of subsets within the CD4+ T cell lineage. It is expressed by activated Th9, Th17, Treg, and Th2 cells. IL-9 acts as an autocrine growth and activation factor for Th17, Treg, and mast cells. It also can inhibit immune responses by enhancing the suppressive properties of Treg and by recruiting immune-suppressive mast cells to sites of inflammation. Mature rat IL-9 shares 58% and 74% amino acid sequence identity with human and mouse IL-9, respectively.
Product Properties
Synonyms
Cytokine P40; HP40
Accession
D4A8l9
GeneID
116558
Source
E.coli-derived Rat IL-9, Gln19-Ala144, with an N-terminal Met.
Molecular Weight
Approximately 14.3 kDa.
AA Sequence
MQRCSTSWGI QHTSYLIENL KDDPSSKCSC SANVTSCLCL PIPSDDCTTP CFQEGMSQVT NATQQSKFSP FFFRVKRIVE TLKSNKCQFF SCEKPCNQTT AGNTVSFLKS LLKTFQKTEV QVQRSRA
Tag
None
Physical Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.
Purity
> 97% by SDS-PAGE and HPLC analyses.
Biological Activity
The ED50 as determined by a cell proliferation assay using murine TS1 cells is less than 10 ng/mL, corresponding to a specific activity of > 1.0 × 105 IU/mg. Fully biologically active when compared to standard.
Endotoxin
< 0.1 EU per 1μg of the protein by the LAL method.
Formulation
Lyophilized from a 0.2 µm filtered concentrated solution in PBS, pH 7.4.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20°C. Further dilutions should be made in appropriate buffered solutions.
Shipping and Storage
The products are shipped with ice pack and can be stored at -20℃ to -80℃ for 1 year.
Recommend to aliquot the protein into smaller quantities when first used and avoid repeated freeze-thaw cycles.
Cautions
1. Avoid repeated freeze-thaw cycles.
2. For your safety and health, please wear lab coats and disposable gloves for operation.
3. For research use only!
HB220425