Iterative Crystallography Service：The neurotrophin-3 and p75NTR symmetrical
产品名称： Iterative Crystallography Service：The neurotrophin-3 and p75NTR symmetrical
英文名称： Iterative Crystallography Service：The neurotrophin-3 and p75NTR symmetrical
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http://www.creative-biostructure.com/Iterative-crystallography/Iterative-crystallography-CBCRY18.htm
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Cat. No. |
CBCRY18 |
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Background |
Neurotrophins (NTs) are important regulators for the survival, differentiation and maintenance of different peripheral and central neurons. NTs bind to two distinct classes of glycosylated receptor: the p75 neurotrophin receptor (p75(NTR)) and tyrosine kinase receptors (Trks). Whereas p75(NTR) binds to all NTs, the Trk subtypes are specific for each NT. |
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Molecular description |
Protein Classification |
signaling protein |
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Structure Weight |
63861.22 |
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Polymer |
1 |
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Molecule |
Neurotrophin-3 |
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Chain Length |
119 amino acids |
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Polymer |
2 |
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Molecule |
Tumor necrosis factor receptor superfamily member 16 |
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Chain Length |
167 amino acids |
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Crystal Description |
PDB ID |
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MMDB ID |
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Source |
E.coli |
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Method |
X-Ray Diffraction |
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Resolution |
2.6Å |
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Ligand Chemical Component |
N-Acetyl-D-Glucosamine |
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Gene information |
Gene Name |
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Synonyms |
HDNF; MGC129711; NGF-2; NGF2; NT3; Nerve growth factor 2; neurotrophic factor; neurotrophin 3 |
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UniProt ID |
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GeneID |
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Chromosome Location |
12p13 |
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Function |
growth factor activity; nerve growth factor binding; neurotrophin receptor binding |
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Gene Name |
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Synonyms |
CD271; Gp80-LNGFR; TNFRSF16; p75(NTR); p75NTR; low affinity nerve growth factor receptor; low-affinity nerve growth factor receptor; nerve growth factor receptor; CD271 antigen; NGF receptor; nerve growth factor receptor |
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UniProt ID |
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GeneID |
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Chromosome Location |
17q21-q22 |
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Function |
death receptor activity; nerve growth factor binding; protein binding |
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Reference |
Gong, Y., Cao, P., Yu, H.J., Jiang, T. (2008) Crystal structure of the neurotrophin-3 and p75NTR symmetrical complex. Nature 454: 789-793 |
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