Anti-PCK1/FITC Conjugated抗体-抗体-抗体-生物在线
Anti-PCK1/FITC Conjugated抗体

Anti-PCK1/FITC Conjugated抗体

商家询价

产品名称: Anti-PCK1/FITC Conjugated抗体

英文名称: Anti-PCK1/FITC

产品编号: YB--5001R-FITC

产品价格: null

产品产地: 中国/美国

品牌商标: Ybscience

更新时间: 2023-08-17T10:29:50

使用范围: 科研使用

上海钰博生物科技有限公司
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  • 邮箱 : shybio@126.com

 Anti-PCK1/FITC Conjugated抗体

产品编号 YB-5001R-FITC
英文名称 Anti-PCK1/FITC
中文名称 FITC标记的磷酸烯醇丙酮酸羧激酶抗体
别    名 PCK1; PEPC; GTP; MGC22652; PEP carboxykinase; PEPCK 1; PEPCK1; PEPCKC; Phosphoenolpyruvate carboxykinase 1; Phosphoenolpyruvate carboxylase; Phosphopyruvate carboxylase.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  细胞生物  免疫学  神经生物学  激酶和磷酸酶  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, 
产品应用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 69kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human PEPC
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
PCK1 is a main control point for the regulation of gluconeogenesis. This cytosolic enzyme, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of the corresponding gene can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet. A mitochondrial isozyme has also been characterized.

Function:
Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.

Subunit:
Monomer.

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Major sites of expression are liver, kidney and adipocytes.

Post-translational modifications:
Acetylation is increased on addition of glucose and appears to regulate the protein stability.

DISEASE:
Defects in PCK1 are the cause of cytosolic phosphoenolpyruvate carboxykinase deficiency (C-PEPCKD) [MIM:261680]. A metabolic disorder resulting from impaired gluconeogenesis. It is a rare disease with less than 10 cases reported in the literature. Clinical characteristics include hypotonia, hepatomegaly, failure to thrive, lactic acidosis and hypoglycemia. Autoposy reveals fatty infiltration of both the liver and kidneys. The disorder is transmitted as an autosomal recessive trait.

Similarity:
Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.

Database links:

Entrez Gene: 5105 Human

Entrez Gene: 18534 Mouse

Entrez Gene: 362282 Rat

Omim: 614168 Human

SwissProt: P35558 Human

SwissProt: Q9Z2V4 Mouse

SwissProt: P07379 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.