Size  100ug
Cat code  200668
Species Cross-reactivity  H,M,R
Key Application  WB
Host  Mouse
Antibody type  Monoclonal antibody
Purified method  Affinity purified
Isotype  IgG1
Molecular Weight  64kDa
Sensitivity  This antibody detects endogenous levels of ATIC and does not cross-react with related proteins.
Immunogen  Purified recombinant human ATIC protein fragments expressed in E.coli.
UniProt Number  P31939
GeneBank ID  NM_004044.6
Subcellular location  null
Formulation  Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%,glycerol
Altername  5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase,AICAR transformylase2.IMP cyclohydrolase,ATIC,IMP synthase Inosinicase
Gene_symbol  PURH; AICAR; AICARFT; IMPCHASE 
Summary  This gene encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. The N-terminal domain has phosphoribosylaminoimidazolecarboxamide formyltransferase activity, and the C-terminal domain has IMP cyclohydrolase activity. A mutation in this gene results in AICA-ribosiduria.
UniPort summary  Function  Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis.
Application Images :  
Western blot detection of ATIC in various tissue and cell lysates using ATIC antibody (1:1000 diluted).
Predicted band size:64KDa.
Observed band size:64KDa