LAP1,层粘连相关多肽蛋白1抗体

产品编号HZ-11351R
英文名称LAP1
中文名称层粘连相关多肽蛋白1抗体
别 名Densin 180; Densin; Densin-180; densin180; DKFZp686I1147; KIAA1365; Lamin associated polypeptide 1; LAP 1; Leucine rich repeat containing 7; Leucine rich repeat containing protein 7; Leucine-rich repeat-containing protein 7; Lrrc 7; Lrrc7; LRRC7_HUMAN; MGC144918; OTTHUMP00000065336; OTTHUMP00000065337; OTTHUMP00000065338; Protein Lap 1; Protein lap1.
说 明 书0.1ml 0.2ml
研究领域细胞生物 神经生物学 信号转导 细胞骨架
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
LAP1,层粘连相关多肽蛋白1抗体产品应用ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量173kDa
细胞定位细胞浆 细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Densin180
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
LAP1,层粘连相关多肽蛋白1抗体PubMedPubMed
产品介绍background:
Densin-180 is a synaptic transmembrane protein that is tightly associated with the postsynaptic density in CNS neurons and is postulated to function as a synaptic adhesion molecule. Densin-180 is a brain-specific momber of the O-sialoglycoprotein family which is highly concentrated at synapses along dendrites. The sequence of densin-180 contains 17 leucine-rich repeats, a sialomucin domain, an apparent transmembrane domain, and a PDZ (PSD-95, DIg, Z0-1) domain. The PDZ domain contributes to its binding to a-actinin. The intracellular portion of densin-180, CaMKIIa, interacts with a-actinin at distinct binding sites and, together, they form a ternary complex stabilized by multiple interactions.

Function:
Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term depression.

Subunit:
Interacts with CAMKII, CNKSR2 and DLG4 (By similarity). Interacts with CTNND2/Catenin delta-2. Forms a complex with N-cadherin through CTNND2.

Subcellular Location:
Cytoplasm. Cell junction > synapse > postsynaptic cell membrane > postsynaptic density.

Tissue Specificity:
Brain-specific. Isoform 3 is ubiquitously expressed.

Similarity:
Belongs to the LAP (LRR and PDZ) protein family.
Contains 17 LRR (leucine-rich) repeats.
Contains 1 PDZ (DHR) domain.

LAP1,层粘连相关多肽蛋白1抗体Database links:
Entrez Gene: 57554 Human
Entrez Gene: 242274 Mouse
Entrez Gene: 117284 Rat
SwissProt: Q96NW7 Human
SwissProt: Q80TE7 Mouse
SwissProt: P70587 Rat
Unigene: 479658 Human
Unigene: 132162 Mouse
Unigene: 89629 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.